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IJEB Vol.47(12) [December 2009] >


Title: Reversal of effects of intra peritoneally administered beryllium nitrate by tiron and CaNa3DTPA alone or in combination with -tocopherol
Authors: Nirala, Satendra Kumar
Bhadauria, Monika
Upadhyay, Anil Kumar
Mathur, Ramesh
Mathur, Asha
Keywords: -tocopherol
Beryllium toxicity
CaNa3 DTPA
Combination therapy
Tiron
Issue Date: Dec-2009
Publisher: CSIR
Abstract: To evaluate therapeutic efficacy of chelating agents tiron (Sodium-4,5-dihydroxy-1,3-benzene disulphonate) and CaNa3DTPA (Calcium trisodium diethylene triamine pentaacetic acid) in presence of -tocopherol against beryllium induced toxicity, adult female albino rats were exposed to beryllium nitrate for 28 days followed by therapy with tiron (471 mg/kg, ip) and CaNa3DTPA (35 mg/kg, ip) alone and in combination with -tocopherol (25 mg/kg, po). Results revealed non-significant fall in haemoglobin and total serum protein content while significant fall in blood sugar level and activity of serum alkaline phosphatase. On the other hand, significant rise in the activity of serum transaminases and LDH was noticed after beryllium administration. Significant increase in total and esterified cholesterol was found in liver and kidney after toxicity. Significant increase in lipid peroxidation and decreased level of reduced glutathione in both the organs showed oxidative stress due to beryllium exposure. Histopathological and ultrastructural observations of liver and kidney revealed lesions due to beryllium toxicity followed by recovery due to combined therapy. CaNa3DTPA showed moderate therapeutic efficacy; however, its effectiveness was enhanced with -tocopherol to some extent. Tiron in combination with -tocopherol exerted statistically more beneficial effects in reversal of beryllium induced biochemical, histopathological and ultrastructural alterations.
Page(s): 955-963
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.47(12) [December 2009]

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