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Title: Manufacture of therapeutic oligonucleotides: Development of new reagents and processes
Authors: Sinha, Nanda D
Kuchimanchi, Satya N
Miranda, Greg
Shaikh, Saied
Keywords: Oligonucleotides;manufacture;antisense;RNAi (RNA interfererence);aptamer;green chemistry
Issue Date: Oct-2006
Publisher: CSIR
IPC Code: Int.Cl.8C07D
Abstract: The optimization of synthesis, purification process parameters and development of new reagents have enabled successful large-scale manufacture of several therapeutic grade oligonucleotides at Avecia. The development of new reagents and processes are described in this communication.
Page(s): 2297-2304
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(10) [October 2006]

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