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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(10) [October 2006] >
| Title: | Manufacture of therapeutic oligonucleotides: Development of new reagents and processes |
| Authors: | Sinha, Nanda D
Kuchimanchi, Satya N
Miranda, Greg
Shaikh, Saied |
| Keywords: | Oligonucleotides
manufacture
antisense
RNAi (RNA interfererence)
aptamer
green chemistry |
| Issue Date: | Oct-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.8C07D |
| Abstract: | The optimization of synthesis, purification process parameters and development of new reagents have enabled successful large-scale manufacture of several therapeutic grade oligonucleotides at Avecia. The development of new reagents and processes are described in this communication. |
| Page(s): | 2297-2304 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(10) [October 2006]
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