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Title: Antimicrobial activity of 1-[<i style="">p</i>{3'-(2'-aryl- 4-oxo-1',3'-thiazolyl)} diphenyl]/[3'-(2'-aryl-4-oxo-1',3'-thiazolyl)]-2-phenyl- 4-cyclohexylidene imidazol-5-ones
Authors: Bishnoi, Abha
Srivastava, Krishna
Tripathi, C K M
Keywords: Oxozolone
hippuric acid
acetic anhydride
thioglycollic acid
Issue Date: Sep-2006
Publisher: CSIR
Series/Report no.: Int. Cl.<sup>8</sup> C07D
Abstract: 2-Phenyl-4-cyclohexylidene-1,3-oxozol-5-one <b style="">1</b> has been obtained from the condensation of hippuric acid and cyclohexane using acetic anhydride. The compound <b style="">1</b> is then converted to its respective imidazoles <b style="">2</b> and <b style="">3</b> by condensing with benzidene and hydrazine hydrate. Which on heating with different aromatic aldehydes give 1-(<i style="">p</i>-arylidene-amino-diphenyl)/(arylidene-amino)-2-phenyl-4-cycohexlyidene imidazol-5-one <b style="">4 </b>and <b style="">5</b>. Interaction of <b style="">4 </b>and <b style="">5</b> with thioglycollic acid undergo cyclization to give titled compounds <b style="">6</b> and <b style="">7</b>. The new compounds have been screened for their antimicrobial activity.
Description: 2136-2139
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(09) [September 2006]

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