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Title: Synthesis of some substituted azetidinonyl and thiazolidinonyl-1,3,4-thiadiazino[6,5-b]indoles as prospective antimicrobial agents
Authors: Panwar, Hemant
Verma, R S
Srivastava, V K
Kumar, Ashok
Keywords: Benzylidenaminoindoles;azetidinon-3-yl-1,3,4-thiadiazino[6,5-b] indoles;antibacterial activity;antifungal activity
Issue Date: Sep-2006
Publisher: CSIR
IPC Code: Int.Cl.8 C07D
Abstract: Several 2-[(3-chloro-2-substituted phenyl)-4-azetidinon-3-yl]-1,3,4-thiadiazino[6,5-b]indoles and 2-[(2-substituted phenyl)-4-thiazolidinon-3-yl]-1,3,4-thiadiazino[6,5-b]indoles have been synthesized. The structures of the synthesized compounds are characterized by elemental and spectral analysis. These compounds are also evaluated for their antimicrobial susceptibility test against S.aureus, E.coli, K.pneumoniae, P.vulgaris and A.fumigatus, C.albicans, A. albicans ATCC, C. krusei G03 respectively. Compounds 4c and 5e showed the most potent antibacrerial and antifungal activities. These two compounds are devoid of any toxicity.
Page(s): 2099-2104
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(09) [September 2006]

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