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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(09) [September 2006] >
| Title: | Synthesis of some substituted azetidinonyl and thiazolidinonyl-1,3,4-thiadiazino[6,5-b]indoles as prospective antimicrobial agents |
| Authors: | Panwar, Hemant
Verma, R S
Srivastava, V K
Kumar, Ashok |
| Keywords: | Benzylidenaminoindoles
azetidinon-3-yl-1,3,4-thiadiazino[6,5-b] indoles
antibacterial activity
antifungal activity |
| Issue Date: | Sep-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.8 C07D |
| Abstract: | Several 2-[(3-chloro-2-substituted phenyl)-4-azetidinon-3-yl]-1,3,4-thiadiazino[6,5-b]indoles and 2-[(2-substituted phenyl)-4-thiazolidinon-3-yl]-1,3,4-thiadiazino[6,5-b]indoles have been synthesized. The structures of the synthesized compounds are characterized by elemental and spectral analysis. These compounds are also evaluated for their antimicrobial susceptibility test against S.aureus, E.coli, K.pneumoniae, P.vulgaris and A.fumigatus, C.albicans, A. albicans ATCC, C. krusei G03 respectively. Compounds 4c and 5e showed the most potent antibacrerial and antifungal activities. These two compounds are devoid of any toxicity. |
| Page(s): | 2099-2104 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(09) [September 2006]
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