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Title: Synthesis of some substituted azetidinonyl and thiazolidinonyl-1,3,4-thiadiazino[6,5-<i style="">b</i>]indoles as prospective antimicrobial agents
Authors: Panwar, Hemant
Verma, R S
Srivastava, V K
Kumar, Ashok
Keywords: Benzylidenaminoindoles
azetidinon-3-yl-1,3,4-thiadiazino[6,5-<i style="">b</i>] indoles
antibacterial activity
antifungal activity
Issue Date: Sep-2006
Publisher: CSIR
Series/Report no.: Int.Cl.<sup>8 </sup>C07D
Abstract: Several 2-[(3-chloro-2-substituted phenyl)-4-azetidinon-3-yl]-1,3,4-thiadiazino[6,5-<i style="">b</i>]indoles and 2-[(2-substituted phenyl)-4-thiazolidinon-3-yl]-1,3,4-thiadiazino[6,5-<i style="">b</i>]indoles have been synthesized. The structures of the synthesized compounds are characterized by elemental and spectral analysis. These compounds are also evaluated for their antimicrobial susceptibility test against <i style="">S.aureus, E.coli, K.pneumoniae, P.vulgaris </i>and<i style=""> A.fumigatus, C.albicans, A. albicans ATCC, C. krusei G03</i> respectively. Compounds <b style="">4c</b> and <b style="">5e</b> showed the most potent antibacrerial and antifungal activities. These two compounds are devoid of any toxicity.
Description: 2099-2104
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(09) [September 2006]

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