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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(09) [September 2006] >
| Title: | Synthesis of [2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6- carbonyl)-1H-indol-3-yl]acetic acids as potential COX-2 inhibitors |
| Authors: | Dubey, P K
Kumar, T Venkateshwar
Reddanna, P
Kumar, K Anil |
| Keywords: | COX-2 inihibitors
inflammation
acrylic acid methylester
indole acetic acid
benzoxazinone |
| Issue Date: | Sep-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.8 C07D |
| Abstract: | The synthesis of potential COX-2 inhibitors by means of internal Michael addition of ortho toluenesulfonylaminophenyl acrylic acid methyl esters 5a-d with 6-(chloroacetyl)-2H-1,4-bezoxazin-4H-ones 6a-c followed by hydrolysis resulting in the formation of [2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-carbonyl)-1H-indol-3-yl]acetic acids 1a-k are reported. |
| Page(s): | 2128-2132 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(09) [September 2006]
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