Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6679
Title: Synthesis of [2-(3-oxo-3,4-dihydro-2<i style="">H</i>-benzo[1,4]oxazin-6- carbonyl)-1<i style="">H</i>-indol-3-yl]acetic acids as potential COX-2 inhibitors
Authors: Dubey, P K
Kumar, T Venkateshwar
Reddanna, P
Kumar, K Anil
Keywords: COX-2 inihibitors
inflammation
acrylic acid methylester
indole acetic acid
benzoxazinone
Issue Date: Sep-2006
Publisher: CSIR
Series/Report no.: Int.Cl.<sup>8</sup> C07D
Abstract: The synthesis of potential COX-2 inhibitors by means of internal Michael addition of ortho toluenesulfonylaminophenyl acrylic acid methyl esters <b style="">5a-d</b> with 6-(chloroacetyl)-2<i style="">H</i>-1,4-bezoxazin-4<i style="">H</i>-ones <b style="">6a-c</b> followed by hydrolysis resulting in the formation of [2-(3-oxo-3,4-dihydro-2<i style="">H</i>-benzo[1,4]oxazin-6-carbonyl)-1<i style="">H</i>-indol-3-yl]acetic acids <b style="">1a-k</b> are reported.
Description: 2128-2132
URI: http://hdl.handle.net/123456789/6679
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(09) [September 2006]

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