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Title: Synthesis of [2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6- carbonyl)-1H-indol-3-yl]acetic acids as potential COX-2 inhibitors
Authors: Dubey, P K
Kumar, T Venkateshwar
Reddanna, P
Kumar, K Anil
Keywords: COX-2 inihibitors;inflammation;acrylic acid methylester;indole acetic acid;benzoxazinone
Issue Date: Sep-2006
Publisher: CSIR
IPC Code: Int.Cl.8 C07D
Abstract: The synthesis of potential COX-2 inhibitors by means of internal Michael addition of ortho toluenesulfonylaminophenyl acrylic acid methyl esters 5a-d with 6-(chloroacetyl)-2H-1,4-bezoxazin-4H-ones 6a-c followed by hydrolysis resulting in the formation of [2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-carbonyl)-1H-indol-3-yl]acetic acids 1a-k are reported.
Page(s): 2128-2132
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(09) [September 2006]

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