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IJEB Vol.44(12) [December 2006] >


Title: Impact of feeding ethanolic extract of root bark of Cananga odorata (Lam) on reproductive functions in male rats
Authors: Anitha, P
Indira, M
Keywords: Antifertility
Cananga odorata
Spermatotoxic
Testis
Testosterone
Issue Date: Dec-2006
Publisher: CSIR
Abstract: The 50% ethanolic extract of the root bark of C. odorata administered orally at the dose of 1g/kg body weight /day for 60 days resulted in decreased epididymal sperm motility and sperm count in male albino rats. Morphological abnormalities were also observed in the sperms. The testicular glycogen, the activities of 3β hydroxy steroid dehydrogenase, glucose 6-phosphate dehydrogenase, malic enzyme, sorbitol dehydrogenase in seminal vesicle, fructose in seminal plasma and serum testosterone were significantly decreased in treated group. While testicular cholesterol level, the concentration of the fecal bile acids, urinary excretion of 17 ketosteroids, the activities of 17β hydroxy steroid dehydrogenase, epididymal lactate dehydrogenase and that of testicular HMG CoA reductase were increased in treated group when compared to control. The results suggest that the ethanolic extract of C. odorata possesses the spermatotoxic effects in male albino rats.
Page(s): 976-980
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(12) [December 2006]

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