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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(12) [December 2006] >
| Title: | Impact of feeding ethanolic extract of root bark of Cananga odorata (Lam) on reproductive functions in male rats |
| Authors: | Anitha, P
Indira, M |
| Keywords: | Antifertility
Cananga odorata
Spermatotoxic
Testis
Testosterone |
| Issue Date: | Dec-2006 |
| Publisher: | CSIR |
| Abstract: | The 50% ethanolic extract of the root bark of C. odorata administered orally at the
dose of 1g/kg body weight /day for 60 days resulted in decreased epididymal
sperm motility and sperm count in male albino rats. Morphological abnormalities
were also observed in the sperms. The testicular glycogen, the activities of 3β
hydroxy steroid dehydrogenase, glucose 6-phosphate dehydrogenase, malic enzyme,
sorbitol dehydrogenase in seminal vesicle, fructose in seminal plasma and serum
testosterone were significantly decreased in treated group. While testicular
cholesterol level, the concentration of the fecal bile acids, urinary excretion
of 17 ketosteroids, the activities of 17β hydroxy steroid dehydrogenase,
epididymal lactate dehydrogenase and that of testicular HMG CoA reductase were
increased in treated group when compared to control. The results suggest that
the ethanolic extract of C. odorata possesses
the spermatotoxic effects in male albino rats. |
| Page(s): | 976-980 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(12) [December 2006]
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