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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(12) [December 2006] >
| Title: | Effect of gold on stimulation of reproductive function in immature female albino rats |
| Authors: | Chattopadhyay, Alok
Sarkar, Mahitosh
Biswas, Narendra M |
| Keywords: | Gold
Reproductive function
Rat |
| Issue Date: | Dec-2006 |
| Publisher: | CSIR |
| Abstract: | Significant increase in ovarian and uterine
weight and stimulation of ovarian D5-3 - hydroxysteroid dehydrogenase (D5-3-HSD) activity and elevation of serum estradiol level were observed
following gold chloride (0.2 mg/kg body weight/day), sc administration in immature
female albino rats. Moreover, normal cyclic changes of estrus were found in
vaginal smears of these rats whereas the rats of other groups showed diestrus
phase throughout the period of experiment. Histological study of ovary also
showed Graafian follicle with ovum in rats treated with 0.2 mg/kg/day of gold
proving stimulation of reproductive function, which was not found in the
ovarian histological study of other groups including controls. Thus, the
results suggest a significant stimulatory effect of gold chloride on female
reproductive activity in immature rats. Further, since the above-mentioned
changes were evident at a specific dose of gold chloride, the data may have
some clinical implications on stimulation and enhancement of fertility in
immature female rats. |
| Page(s): | 971-975 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(12) [December 2006]
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