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Title: Influence of transcranial magnetic stimulation on spike-wave discharges in a genetic model of absence epilepsy
Authors: Godlevsky, Leonid S
Kobolev, Evgeniy V
Luijtelaar, Egidius L J M van
Coenen, Antony M L
Stepanenko, Konstantin I
Smirnov, Igor V
Keywords: Absence epilepsy
Spike-wave discharges
Transcranial magnetic stimulation
Issue Date: Dec-2006
Publisher: CSIR
Abstract: Transcranial magnetic stimulation (TMS) impulses, (0.5 Hz, 3 impulses) were presented at threshold intensity to male WAG/Rij rats. One group received stimuli, which involved motor responses of hindlimbs, rats of the second group received sham stimulation. Electrocorticograms (ECoG) were recorded before and up to 2 hr from the moment of transcranial magnetic stimulation. It was established that such stimulation engendered a reduction of spike-wave discharge (SWD) bursts duration. This effect was most pronounced in 30 min from the moment of cessation of stimulation, when a decrease of 31.4% was noted in comparison with sham-stimulated control group. The number of bursts of spike-wave discharges was reduced, but did not reach significant difference when compared both with pre-stimulative base-line level and with sham- stimulated control rats. Bursts of spike- wave discharges restored up to pre-stimulative level in 90-150 minutes from the moment of cessation of transcranial stimulation. It can be concluded that transcranical magnetic stimulation possessed an ability to engender short- time suppression of bursts of spike-wave discharges in WAG/Rij rats.
Page(s): 949-954
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(12) [December 2006]

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