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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(12) [December 2006] >
| Title: | Influence of transcranial magnetic stimulation on spike-wave discharges in a genetic model of absence epilepsy |
| Authors: | Godlevsky, Leonid S
Kobolev, Evgeniy V
Luijtelaar, Egidius L J M van
Coenen, Antony M L
Stepanenko, Konstantin I
Smirnov, Igor V |
| Keywords: | Absence epilepsy
Spike-wave discharges
Transcranial magnetic stimulation |
| Issue Date: | Dec-2006 |
| Publisher: | CSIR |
| Abstract: | Transcranial magnetic
stimulation (TMS) impulses, (0.5 Hz, 3 impulses) were presented at threshold
intensity to male WAG/Rij rats. One group received stimuli, which involved
motor responses of hindlimbs, rats of the second group received sham
stimulation. Electrocorticograms (ECoG) were recorded before and up to 2 hr
from the moment of transcranial magnetic stimulation. It was established that
such stimulation engendered a reduction of spike-wave discharge (SWD) bursts
duration. This effect was most pronounced in 30 min from the moment of
cessation of stimulation, when a decrease of 31.4% was noted in comparison with
sham-stimulated control group. The number of bursts of spike-wave discharges
was reduced, but did not reach significant difference when compared both with
pre-stimulative base-line level and with sham- stimulated control rats. Bursts
of spike- wave discharges restored up to pre-stimulative level in 90-150
minutes from the moment of cessation of transcranial stimulation. It can be
concluded that transcranical magnetic stimulation possessed an ability to
engender short- time suppression of bursts of spike-wave discharges in WAG/Rij
rats. |
| Page(s): | 949-954 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(12) [December 2006]
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