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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(11) [November 2006] >
| Title: | Ethanolic Zingiber officinale R. extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats |
| Authors: | Ansari, M Nazam
Bhandari, U
Pillai, K K |
| Keywords: | Creatine kinase
Isoproterenol
Myocardial necrosis
Zingiber officinale |
| Issue Date: | Nov-2006 |
| Publisher: | CSIR |
| Abstract: | Ethanolic Z. officinale (ZO) extract (200 mg/kg)
pretreatment for 20 days in isoproterenol (ISO)-treated rats significantly
increased the levels of endogenous myocardial antioxidants (catalase,
superoxide dismutase and tissue glutathione), decreased the levels of serum
marker enzymes (lactate dehydrogenase, creatine kinase, aspartate transaminase
and alanine transaminase) and increased myocardial lipid peroxides.
Histological examination of rat’s heart section confirmed myocardial injury
with ISO administration and near normal pattern with ethanolic ZO extract
pretreatment. The results of the present study, for the first time, provide
clear evidence that the ethanolic ZO extract pretreatment enhances the antioxidant
defense against ISO-induced oxidative myocardial injury in rats and exhibit
cardioprotective property. |
| Page(s): | 892-897 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(11) [November 2006]
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