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IJEB Vol.44(11) [November 2006] >


Title: Ethanolic Zingiber officinale R. extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats
Authors: Ansari, M Nazam
Bhandari, U
Pillai, K K
Keywords: Creatine kinase
Isoproterenol
Myocardial necrosis
Zingiber officinale
Issue Date: Nov-2006
Publisher: CSIR
Abstract: Ethanolic Z. officinale (ZO) extract (200 mg/kg) pretreatment for 20 days in isoproterenol (ISO)-treated rats significantly increased the levels of endogenous myocardial antioxidants (catalase, superoxide dismutase and tissue glutathione), decreased the levels of serum marker enzymes (lactate dehydrogenase, creatine kinase, aspartate transaminase and alanine transaminase) and increased myocardial lipid peroxides. Histological examination of rat’s heart section confirmed myocardial injury with ISO administration and near normal pattern with ethanolic ZO extract pretreatment. The results of the present study, for the first time, provide clear evidence that the ethanolic ZO extract pretreatment enhances the antioxidant defense against ISO-induced oxidative myocardial injury in rats and exhibit cardioprotective property.
Page(s): 892-897
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(11) [November 2006]

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