NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(11) [November 2006] >

Title: Effect of increased calcium intake on cardiac and vascular Na+ - K+ - ATPase activity in oral contraceptive-treated female Sprague-Dawley rats
Authors: Olatunji, L A
Soladoye, A O
Keywords: Dietary calcium
Na+-K+-ATPase activity
Oral contraceptive
Issue Date: Nov-2006
Publisher: CSIR
Abstract: The present study aimed at investigating the influence of increased dietary calcium on Na+-K+-ATPase activity in heart and aorta of female Sprague-Dawley rats treated with oral contraceptive (OC) steroids. Rats were grouped as control (CR), OC-treated and OC+calcium-treated. OC-treated and OC+calcium-treated received a combination of OC steriods (ethinyloestradiol and norgestrel; ig). OC+calcium-treated rats were fed with 2.5% calcium diet, while OC-treated and CR groups were fed on 0.9% calcium diet. The activity of Na+-K+-ATPase in heart and aorta was significantly lower in OC-treated rats than those in the other groups. OC treatment caused significant increase in plasma glucose and significant decrease in plasma K+ as compared to control group. Decrease in Na+-K+-ATPase activity and plasma K+ was abrogated by increased calcium intake, while increase in plasma glucose was not normalized by calcium supplementation. Plasma levels of Na+, lipid peroxidation index and ascorbic acid were comparable among the three groups. These results showed that OC treatment could lead to impaired activity of cardiac and vascular Na+-K+-ATPase, possibly due to reduced plasma K+ level and these effects could be abolished by high calcium diet.
Page(s): 875-879
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(11) [November 2006]

Files in This Item:

File Description SizeFormat
IJEB 44(11) 875-879.pdf164.37 kBAdobe PDFView/Open
 Current Page Visits: 65 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 162864 since 01-Sep-2015  Last updated on 21-Jun-2016Webmaster: