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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(11) [November 2006] >
| Title: | Effect of increased calcium intake on cardiac and vascular Na+ - K+ - ATPase activity in oral contraceptive-treated female Sprague-Dawley rats |
| Authors: | Olatunji, L A
Soladoye, A O |
| Keywords: | Dietary calcium
Hypokalaemia
Na+-K+-ATPase activity
Oral contraceptive |
| Issue Date: | Nov-2006 |
| Publisher: | CSIR |
| Abstract: | The present
study aimed at investigating the influence of increased dietary calcium on Na+-K+-ATPase
activity in heart and aorta of female Sprague-Dawley
rats treated with oral contraceptive (OC) steroids. Rats were grouped as
control (CR), OC-treated and OC+calcium-treated. OC-treated and
OC+calcium-treated received a combination of OC steriods (ethinyloestradiol and
norgestrel; ig). OC+calcium-treated rats were fed with 2.5% calcium diet, while
OC-treated and CR groups were fed on 0.9% calcium diet. The activity of Na+-K+-ATPase
in heart and aorta was significantly lower in OC-treated rats than those in the
other groups. OC treatment caused significant increase in plasma glucose and
significant decrease in plasma K+ as compared to control group.
Decrease in Na+-K+-ATPase activity and plasma K+ was
abrogated by increased calcium intake, while increase in plasma glucose was not
normalized by calcium supplementation. Plasma levels of Na+, lipid
peroxidation index and ascorbic acid were comparable among the three groups.
These results showed that OC treatment could lead to impaired activity of cardiac
and vascular Na+-K+-ATPase, possibly due to reduced
plasma K+ level and these effects could be abolished by high calcium
diet. |
| Page(s): | 875-879 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(11) [November 2006]
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