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Title: Effect of increased calcium intake on cardiac and vascular Na+ - K+ - ATPase activity in oral contraceptive-treated female Sprague-Dawley rats
Authors: Olatunji, L A
Soladoye, A O
Keywords: Dietary calcium
Hypokalaemia
Na+-K+-ATPase activity
Oral contraceptive
Issue Date: Nov-2006
Publisher: CSIR
Abstract: The present study aimed at investigating the influence of increased dietary calcium on Na+-K+-ATPase activity in heart and aorta of female Sprague-Dawley rats treated with oral contraceptive (OC) steroids. Rats were grouped as control (CR), OC-treated and OC+calcium-treated. OC-treated and OC+calcium-treated received a combination of OC steriods (ethinyloestradiol and norgestrel; ig). OC+calcium-treated rats were fed with 2.5% calcium diet, while OC-treated and CR groups were fed on 0.9% calcium diet. The activity of Na+-K+-ATPase in heart and aorta was significantly lower in OC-treated rats than those in the other groups. OC treatment caused significant increase in plasma glucose and significant decrease in plasma K+ as compared to control group. Decrease in Na+-K+-ATPase activity and plasma K+ was abrogated by increased calcium intake, while increase in plasma glucose was not normalized by calcium supplementation. Plasma levels of Na+, lipid peroxidation index and ascorbic acid were comparable among the three groups. These results showed that OC treatment could lead to impaired activity of cardiac and vascular Na+-K+-ATPase, possibly due to reduced plasma K+ level and these effects could be abolished by high calcium diet.
Page(s): 875-879
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(11) [November 2006]

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