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Title: Synthesis of Fmoc-protected <i style="">β</i>-amino alcohols and peptidyl alcohols from Fmoc-amino acid / peptide acid azides
Authors: Babu, Vommina V Suresh
Sudarshan, Naremaddepalli S
Keywords: Fmoc-<i style="">β</i>-amino alcohols
Fmoc-<i style=""><img src='/image/spc_char/alpha.gif' border=0> </i>-amino acyl azides
Issue Date: Aug-2006
Publisher: CSIR
Series/Report no.: Int.Cl.<sup>8</sup> C07D
Abstract: An efficient synthesis of <i style="">N<sup><img src='/image/spc_char/alpha.gif' border=0></sup></i>-9<i style="">H</i>-fluoren-9-ylmethoxycarbonyl(Fmoc)-<i style="">β</i>-amino alcohols by the reduction of Fmoc-<i style=""><img src='/image/spc_char/alpha.gif' border=0></i>-amino acyl azides employing aqueous NaBH<sub>4</sub> as a reducing agent has been described. The reduction is found to be simple and almost complete. All the Fmoc-<i style="">β</i>-amino alcohols prepared are fully characterized by <sup>1</sup>H and <sup>13</sup>C NMR and mass spectrometry. Further, the method is extended for the reduction of seven Fmoc-dipeptidyl acids to the corresponding alcohols. Their reduction is also found to be smooth and complete.
Description: 1880-1886
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(08) [August 2006]

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