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IJC-B Vol.45B(08) [August 2006] >

Title: Synthesis of Fmoc-protected β-amino alcohols and peptidyl alcohols from Fmoc-amino acid / peptide acid azides
Authors: Babu, Vommina V Suresh
Sudarshan, Naremaddepalli S
Keywords: Fmoc-β-amino alcohols
Fmoc- -amino acyl azides
Issue Date: Aug-2006
Publisher: CSIR
IPC CodeInt.Cl.8 C07D
Abstract: An efficient synthesis of N-9H-fluoren-9-ylmethoxycarbonyl(Fmoc)-β-amino alcohols by the reduction of Fmoc--amino acyl azides employing aqueous NaBH4 as a reducing agent has been described. The reduction is found to be simple and almost complete. All the Fmoc-β-amino alcohols prepared are fully characterized by 1H and 13C NMR and mass spectrometry. Further, the method is extended for the reduction of seven Fmoc-dipeptidyl acids to the corresponding alcohols. Their reduction is also found to be smooth and complete.
Page(s): 1880-1886
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(08) [August 2006]

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