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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(08) [August 2006] >
| Title: | Synthesis of Fmoc-protected β-amino alcohols and peptidyl alcohols from Fmoc-amino acid / peptide acid azides |
| Authors: | Babu, Vommina V Suresh
Kantharaju
Sudarshan, Naremaddepalli S |
| Keywords: | Fmoc-β-amino alcohols
Fmoc- -amino acyl azides |
| Issue Date: | Aug-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.8 C07D |
| Abstract: | An efficient synthesis of N-9H-fluoren-9-ylmethoxycarbonyl(Fmoc)-β-amino alcohols by the reduction of Fmoc--amino acyl azides employing aqueous NaBH4 as a reducing agent has been described. The reduction is found to be simple and almost complete. All the Fmoc-β-amino alcohols prepared are fully characterized by 1H and 13C NMR and mass spectrometry. Further, the method is extended for the reduction of seven Fmoc-dipeptidyl acids to the corresponding alcohols. Their reduction is also found to be smooth and complete. |
| Page(s): | 1880-1886 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(08) [August 2006]
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