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IJC-B Vol.45B(08) [August 2006] >


Title: Synthesis and antibacterial activity of 1,3,4-oxadiazolyl-1,8-naphthyridines
Authors: Mogilaiah, K
Vidya, K
Keywords: 1,8-Naphthyridinyl acetic acid hydrazide
acetophenones
condensation
1,8-naphthyridinyl methylcarbonyl hydrazones acetic anhydride
cyclization
1,3,4-oxadiazolyl-1, 8-naphthyridines
Issue Date: Aug-2006
Publisher: CSIR
IPC CodeInt. Cl.8 C07D
Abstract: Condensation of (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)-acetic acid hydrazide 2 with different acetophenones yields the corresponding acetophenone (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)methylcarbonyl hydrazones 3, which on treatment with acetic anhydride affords the respective 1-(4-acetyl-5-aryl-5-methyl-[1,3,4]oxadiazol-2-ylmethyl)-3-phenyl-1H-[1,8]naphthyridin-2-ones 4. The structures of the compounds 3 and 4 have been confirmed on the basis of analytical and spectral data. The compounds 4 have been screened for their antibacterial activity.
Page(s): 1905-1908
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(08) [August 2006]

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