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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(08) [August 2006] >
| Title: | Synthesis, characterization and in vitro anti-JEV activity of N-[p-{3'-(2'-aryl-4'-oxo-1',3'-thiazolyl)} diphenyl]-7-hydroxy-4-methyl-2-oxoquinolines |
| Authors: | Bishnoi, Abha
Srivastava, Krishna
Joshi, M N |
| Keywords: | N-(p-aminodiphenyl)-7-hydroxy-4-methyl-2-oxoqui-noline
7-hydroxy-4-methyl-coumarin
thioglycollic acid
benzidine
ethylacetotate
arylaldehyde |
| Issue Date: | Aug-2006 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl.8 C07D |
| Abstract: | The synthesis of N-[p-{3'-(2'-aryl-4'-oxo-1',3'-thiazolyl)}diphenyl]-7-hydroxy-4-methyl-2-oxoquinolines 4 have been achieved starting from resorcinol. 7-hydroxy-4-methylcoumarin(4-methylumbelliferone) 1 is obtained by the reaction of resorcinol with ethylacetoacetate. 1 on treatment with benzidine gives N-(p-aminodiphenyl)-7-hydroxy-4-methyl-2-oxoquinoline 2. 2 on treatment with different aryl aldehydes in presence of glacial acetic acid furnishes_N-(p-arylidinoamino-diphenyl-7-hydroxy-4-methyl-2-oxoquinolines 3a-e. The latter on treatment with thioglycollic acid in presence of anhydrous ZnCl2 yields 4a-e. The in vitro anti-JEV activity of these compounds has also been evaluated. |
| Page(s): | 1961-1964 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(08) [August 2006]
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