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IJC-B Vol.45B(08) [August 2006] >

Title: Synthesis, characterization and in vitro anti-JEV activity of N-[p-{3'-(2'-aryl-4'-oxo-1',3'-thiazolyl)} diphenyl]-7-hydroxy-4-methyl-2-oxoquinolines
Authors: Bishnoi, Abha
Srivastava, Krishna
Joshi, M N
Keywords: N-(p-aminodiphenyl)-7-hydroxy-4-methyl-2-oxoqui-no¬≠line
thioglycollic acid
Issue Date: Aug-2006
Publisher: CSIR
IPC CodeInt. Cl.8 C07D
Abstract: The synthesis of N-[p-{3'-(2'-aryl-4'-oxo-1',3'-thiazolyl)}diphenyl]-7-hydroxy-4-methyl-2-oxoquinolines 4 have been achieved starting from resorcinol. 7-hydroxy-4-methylcoumarin(4-methylumbelliferone) 1 is obtained by the reaction of resorcinol with ethylacetoacetate. 1 on treatment with benzidine gives N-(p-aminodiphenyl)-7-hydroxy-4-methyl-2-oxoquinoline 2. 2 on treatment with different aryl aldehydes in presence of glacial acetic acid furnishes_N-(p-arylidinoamino-diphenyl-7-hydroxy-4-methyl-2-oxoquinolines 3a-e. The latter on treatment with thioglycollic acid in presence of anhydrous ZnCl2 yields 4a-e. The in vitro anti-JEV activity of these compounds has also been evaluated.
Page(s): 1961-1964
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(08) [August 2006]

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