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IJC-B Vol.45B [2006] >
IJC-B Vol.45B(08) [August 2006] >


Title: Vilsmeier Haack reaction of substituted 2-acetamidothiazole derivatives and their antimicrobial activity
Authors: Koti, R S
Kolavi, G D
Hegde, V S
Khazi, I M
Keywords: 2-Acetamidothiazole
Vilsmeier Haack reaction
N-formylation
deacetylation
antimicrobial activity
Issue Date: Aug-2006
Publisher: CSIR
IPC CodeInt. Cl.8 C07D
Abstract: Vilsmeier Haack (VMH) reaction of 2-acetamidothiazole having carbethoxy group at C-4 affords the unexpected N-formylated product, which is followed by deacetylation. The same reaction with substituents other than carbethoxy group at C-4 position (viz CH3, CH2COOC2H5, coumarinyl, phenyl, etc.) gives the expected C-5 formylated products. The structures of all the newly prepared compounds have been established on the basis of their analytical and spectral data. All the synthesized compounds have been screened for their antimicrobial activity against two strains of bacteria and fungi.
Page(s): 1900-1904
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(08) [August 2006]

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