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Title: Ginseng extract exhibits antimutagenic activity against induced mutagenesis in various strains of <i style="">Salmonella typhimurium</i>
Authors: Geetha, Thiraviam
Saini, Amarpreet
Kaur, Indu Pal
Keywords: Ames test
DPPH assay
Ginseng extract
<i style="">In vitro</i> antioxidant action
Issue Date: Oct-2006
Publisher: CSIR
Abstract: Ginseng has been reported to exhibit antioxidant and antimutagenic activity. The present study was undertaken with a view to confirm whether the antioxidant activity of Ginseng is responsible for its antimutagenic action. The concentrated root extract of <i style="">Panax ginseng </i>(Ginseng extract I) and its lyophilized powder (Ginseng extract II) obtained from two different manufacturing houses, were tested against mutagenesis using the well-standardized Ames microsomal test system. The extracts exhibited antimutagenic effect against hydrogen peroxide induced mutagenesis in TA100 strain, and against mutagenesis produced by 4-nitroquinoline-N-oxide in both TA98 and TA100 strains of <i style="">Salmonella typhimurium</i>. Both the extracts failed to show any antimutagenic potential against <i style="">tert</i>-butyl hydroperoxide (an oxidative mutagen) in TA102 strain, a strain highly sensitive to active oxygen species. The extracts also indicated a weak antioxidant activity in a series of <i style="">in vitro</i> test systems viz., 1,1-diphenyl picryl hydrazyl (DPPH) assay, hydrogen peroxide scavenging and superoxide anion scavenging. The results indicate that the protective effects shown by ginseng extract(s) against 4-nitroquinoline-n-oxide and hydrogen peroxide induced mutagenesis in TA98 and TA100 could mainly be due to its property to initiate and promote DNA repair rather than free radical scavenging action.
Description: 838-841
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(10) [October 2006]

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