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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(10) [October 2006] >
| Title: | Ginseng extract exhibits antimutagenic activity against induced mutagenesis in various strains of Salmonella typhimurium |
| Authors: | Geetha, Thiraviam
Saini, Amarpreet
Kaur, Indu Pal |
| Keywords: | Ames test
Antimutagenicity
DPPH assay
Ginseng extract
In vitro antioxidant action |
| Issue Date: | Oct-2006 |
| Publisher: | CSIR |
| Abstract: | Ginseng has been
reported to exhibit antioxidant and antimutagenic activity. The present study
was undertaken with a view to confirm whether the antioxidant activity of Ginseng
is responsible for its antimutagenic action. The concentrated root extract of Panax ginseng (Ginseng extract I) and
its lyophilized powder (Ginseng extract II) obtained from two different
manufacturing houses, were tested against mutagenesis using the
well-standardized Ames microsomal test system. The extracts exhibited
antimutagenic effect against hydrogen peroxide induced mutagenesis in TA100
strain, and against mutagenesis produced by 4-nitroquinoline-N-oxide in both
TA98 and TA100 strains of Salmonella
typhimurium. Both the extracts failed to show any antimutagenic potential
against tert-butyl hydroperoxide (an
oxidative mutagen) in TA102 strain, a strain highly sensitive to active oxygen
species. The extracts also indicated a weak antioxidant activity in a series of
in vitro test systems viz.,
1,1-diphenyl picryl hydrazyl (DPPH) assay, hydrogen peroxide scavenging and
superoxide anion scavenging. The results indicate that the protective effects
shown by ginseng extract(s) against 4-nitroquinoline-n-oxide and hydrogen
peroxide induced mutagenesis in TA98 and TA100 could mainly be due to its
property to initiate and promote DNA repair rather than free radical scavenging
action. |
| Page(s): | 838-841 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(10) [October 2006]
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