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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(10) [October 2006] >
| Title: | Role of free radicals in stress-induced neurobehavioural changes in rats |
| Authors: | Pal, Rishi
Gulati, Kavita
Chakraborti, Ayanabha
Banerjee, Basudeb
Ray, Arunabha |
| Keywords: | Restraint stress
Elevated plus maze
Open field
Free radicals
Antioxidants |
| Issue Date: | Oct-2006 |
| Publisher: | CSIR |
| Abstract: | Effect of restraint stress (RS) and its
modulation by antioxidants were evaluated on elevated plus maze (EPM) and open
field (OF) tests in rats. Restraint stress (RS for 1hr) reduced the number of
open arm entries, as also the time spent on open arms indicating enhanced
anxiogenic response in the EPM test as compared to normal non RS group of rats.
Pretreatment with ascorbic acid (100 and 200 mg/kg) and a-tocopherol (30 and 60 mg/kg) attenuated these RS-induced effects.
In the OF test, RS-reduced (a) ambulations; and (b) rearings, whereas an
increase was seen in (a) latency of entry and (b) number of fecal boluses. The
RS-induced changes in OF parameters were reversed after pretreatment with the
antioxidants, (ascorbic acid and alpha tocopherol). Biochemical data showed
that RS enhanced MDA levels in both serum and brain, and these were attenuated
after pretreatment with the antioxidants. The pharmacological and biochemical
results indicate that free radicals might be involved in such stress-induced
neurobehavioural effects. |
| Page(s): | 816-820 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(10) [October 2006]
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