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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(10) [October 2006] >
| Title: | Modulation of lecithin activity by vitamin-B complex to treat long term consumption of ethanol induced oxidative stress in liver |
| Authors: | Das, Subir Kumar
Vasudevan, D M |
| Keywords: | Ethanol
Lecithin
Liver
Oxidative stress
Tocopherol
Vitamin-B Complex |
| Issue Date: | Oct-2006 |
| Publisher: | CSIR |
| Abstract: | Alcoholic liver disease (ALD) develops as a
consequence of priming and sensitizing mechanisms rendered by cross-interactions
of primary mechanistic factors and secondary risk factors. Chronic alcohol
abuse and its progression to ALD are associated with abnormal metabolism and
low tissue or plasma levels, or both, of many micronutrients. Glutathione
depletion is considered the most important sensitizing mechanism. In the
present study efficacy of lecithin with vitamin-B complex to treat ethanol
induced oxidative stress was compared with the effect of lecithin alone,
tocopheryl acetate (vitamin E), as well as capacity of hepatic regeneration
during abstention. Ethanol (1.6g / kg body weight/ day for 4 weeks) affects
body weight in 16-18 week old male albino rats of Wistar strain weighing
200-220 g. Thiobarbituric acid reactive substance level, nitrite content, protein
carbonyl group level, redox ratio (oxidized to reduced glutathione ratio),
superoxide dismutase activity, and glutathione s-transferase activity
significantly increased on ethanol exposure. Whereas reduced glutathione
content, and activities of catalase, glutathione reductase and glutathione
peroxidase significantly reduced due to ethanol exposure. These changes were
reversed by different treatment. The results suggest that tocopheryl acetate
(vitamin E) could partially reverse these changes and act as a potential
therapeutic agent. However, lecithin with vitamin-B complex treatment is a
promising therapeutic approach. Furthermore, preventive measures were more
effective than curative treatment. Prevention of oxidative and nitrosative
stress along with correction of nutritional deficiency is one of the proposed
mechanisms for the therapeutic approach. |
| Page(s): | 791-801 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(10) [October 2006]
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