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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(10) [October 2006] >
| Title: | Is the anti-sarcoma and anti-viral cytokine “plasma factor” a novel chicken Y-box protein? |
| Authors: | Shirodkar, Manohar V N
Sehgal, Pravin B |
| Keywords: | Anti-sarcoma
Cytokine
Plasma factor
Y-box protein |
| Issue Date: | Oct-2006 |
| Publisher: | CSIR |
| Abstract: | A line of research beginning in the early
1960s with the observation that West Nile virus and, later, several strains of
rabies virus could inhibit the development of the Rous sarcoma virus-induced
tumor in the wing-web of chicken (a “sarcoma-blockade”) eventually culminated
in the characterization of a 14-kDa circulating anti-sarcoma and anti-viral
activity christened “plasma factor” (PF) which, unlike the interferons,
inhibited the replication of diverse RNA-containing viruses, but not of any
DNA-containing viruses. The possibility that this 14 kDa protein represented a
novel antiviral cytokine has been strengthened by analysis of partial amino
acid sequencing data which suggest that this 14-kDa cytokine may correspond to
the 127-amino acid-long chicken YB2-like protein (Locus: XP_423576) deduced
very recently from the genomic sequencing of chicken. Biologically, proteins of
the Y-box family (such as chicken YB1 and YB2) not only bind DNA and thus
regulate transcription but also bind single-stranded RNA in a sequence-specific
and reversible manner, repress viral RNA translation, inhibit retroviral
transformation of chicken fibroblasts, and are known to regulate transcription
of human immunodeficiency virus and hepatitis B virus. Taken together, the
available data point to a novel anti-viral cytokine with a novel mechanism of
action. |
| Page(s): | 777-782 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(10) [October 2006]
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