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Title: Synthesis and evaluation of some 1, 4-dihydropyridine and their derivatives as antihypertensive agents
Authors: Pattan, Shashikant R
Rasal, V P
VVenkatramana, N
Khade, A B
Butle, S R
Jadhav, S G
Desai, B G
Manvi, F V
Keywords: Antihypertensive;Vasodilators;Antidiabetic;Antitumour;Antimicrobial
Issue Date: Apr-2007
Publisher: CSIR
IPC Code: Int. Cl. ⁸ C07D
Abstract: A series of 1, 4-dihydro-2, 6-dimethyl-4-{4-[3-(2-aminopyrazine/1-amino-4-methyl piperazine)-2-hydroxy propoxy]-phenyl}-pyridine-3, 5-carbamoyl have been synthesized and the structure of the compounds have been confirmed by IR, ¹H NMR , MS & elemental analysis. The title compounds have been evaluated for antihypertensive activity by tail-cuff method. Some of these compounds have been found to exhibit excellent antihypertensive activity.
Page(s): 698-701
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(04) [April 2007]

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