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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(09) [September 2006] >
| Title: | Neuroprotective effect of BDNF in young and aged 6-OHDA treated rat model of Parkinson disease |
| Authors: | Singh, Shalini
Ahmad, Riyaz
Mathur, Deepti
Sagar, Ravinder Kumar
Krishana, Bal
Arora, Rajesh
Sharma, Rakesh Kumar |
| Keywords: | Brain derived neurotrophic factor
Neuroprotection
Parkinson disease
Rat |
| Issue Date: | Sep-2006 |
| Publisher: | CSIR |
| Abstract: | Brain derived neurotrophic factor
(BDNF) has been shown to exert trophic effects on dopaminergic neurons against
6-hydroxydopamine (6-OHDA) in young rat. Since the degeneration of substantia
nigra dopaminergic neurons that occurs in Parkinson’s disease is more often
than not confined to elderly individuals, it is of interest to determine
whether the effects of BDNF against 6 hydroxydopamine (6-OHDA) in young rats
can be extended to aged animals. 6-hydroxydopamine was stereotaxically injected
into the striatum of young (3-months) and aged (24-months) rats, which were
treated two hours earlier with BDNF. 6-OHDA results in almost complete
destruction of substantia nigra pars compacta dopaminergic neurons. BDNF
injection significantly changed apomorphine induced rotations from 132 ± 15
to 181 ±
10, staircase test from 73 ± 2% to 61 ± 3%, initiation time from 7 ± 2 to 12 ± 1 sec, and disengage time
from 80 ±
7 to 90 ± 5 sec in young and aged
animals, respectively. It is concluded that BDNF causes the limited behavior
recovery of striatal DA systems from 6-OHDA toxicity in aged animals. |
| Page(s): | 699-704 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(09) [September 2006]
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