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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(09) [September 2006] >
| Title: | Long term excessive Zn–supplementation promotes metabolic syndrome-X in Wistar rats fed sucrose and fat rich semisynthetic diet |
| Authors: | Taneja, S K
Mandal, R
Girhotra, S |
| Keywords: | Dyslipidemia
Hypertension
Metabolic syndrome-X
NIDDM
Obesity
Zn- supplementation |
| Issue Date: | Sep-2006 |
| Publisher: | CSIR |
| Abstract: | During the last two decades Zinc (Zn) as a
micronutrient is being used indiscriminately in agricultural and husbandry
practices and also in baby foods and multivitamin supplements with a view that
Zn is non-toxic and promotes linear growth and body weight in the consumers.
The long-term effect of increasing Zn load in the body has not been worked out
so far. In this study, three groups of rats were fed on a semi-synthetic diet
containing 20 mg (control, group-I), 40 mg (group-II) and 80 mg Zn /kg
(group-III) diet respectively for 6 months. The results revealed that the gain
in body weight increased in rats in Zn-concentration dependent manner. The urine
examined on weekly basis showed glucosuria in group-II on week 10 and in
group-III on week 8 and thereafter. The arterial blood pressure was
significantly higher in group-II and III than their control counter parts on
monthly basis. Histochemical examination of skin revealed an increase in the
number of adipocytes filled with triglycerides making a subcutaneous fatty
tissue thicker in group-II and group-III than that of control group. The blood
profile after 180 days of dietary treatment, displayed a significant rise in
glucose, total lipids, cholesterol, triglycerides, LDL-cholesterol,
VLDL-cholesterol, insulin, cortisol and aldosterone whereas HDL-cholesterol, T3,
T4 and TSH showed a reduction in their levels in the blood
serum. The tissue metal status showed an increase of Zn, Cu and Mg in the
serum, a rise in Zn in liver, hair and abdominal muscles and fall in Cu and Mg
concentrations in liver, hair and abdominal muscles. This data suggest that Zn
in excess in diet when fed for longer periods of time induces metabolic
syndrome-X. |
| Page(s): | 705-718 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(09) [September 2006]
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