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|Title:||Isomerization of the Baylis-Hillman adducts using amberlyst-15 as a heterogeneous reusable catalyst: a simple and efficient stereoselective synthesis of (<i>E</i>)-cinnamyl alcohol derivatives|
heterogeneous reusable catalyst
|Abstract:||The Baylis-Hillman adducts, 3-aryl-3-hydroxy-2-methylene-alkanoates and 3-aryl-3-hydroxy-2-methylene-alkanenitriles have been efficiently isomerized to the corresponding (<i>E</i>)-cinnamyl alcohols by treatment of the adducts with Ac<sub>2</sub>O in the presence of Amberlyst-15 followed by hydrolysis of the intermediate acetates with K<sub>2</sub>CO<sub>3</sub>/MeOH. The first step occurs under solvent-free conditions and the catalyst has been found to be reusable.|
|Appears in Collections:||IJC-B Vol.45B(07) [July 2006]|
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