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IJC-B Vol.45B [2006] >
IJC-B Vol.45B(07) [July 2006] >


Title: Synthesis of novel substituted / unsubstituted- (2,8-bis-trifluoromethyl-quinolin-4-yloxy)-acetic acid: Derivatives of cephalosporin and their antibacterial activity
Authors: Singh, Santosh Kumar
Nahta, Ajay
Tiwari, R P
Jain, Praveen
Keywords: Quinolinoxy acetic acids
cephalosporins
substituted cephalosporanic acids
hexamethyldisilazane
chloro­rimethylsilane
silylation
antibacterial activity
Issue Date: Jul-2006
Publisher: CSIR
IPC CodeInt.Cl.8C07D
Abstract: Substituted/unsubstituted-(2,8-bis-trifluoromethyl-quinolin-4-yloxy)-acetic acid derivatives of cephalosporin have been synthesized by condensation of acid chlorides of substituted/unsubstituted - (2,8-bis-trifluoromethyl-quinolin-4-yloxy)-acetic acid with various silylated (6R,7R)-7-amino-3-substituted cephalosporanic acids. The products have been tested for their antibacterial activity.
Page(s): 1734-1739
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(07) [July 2006]

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