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Title:  Synthesis of a modified peptide fragment analog Val-Tyr (P)-Val-Ala-Ala-OH of cAMP protein kinase regulatory sub unit type II employing Fmoc chemistry
Authors: Devaraju, Kuramkote Shivanna
Patil, Basanagoud S
Tantry, Subramanyam J
Babu, S V Suresh
Shetty K, Taranath
Babu, Vommina V Suresh
Keywords: Phosphorylation;cAMP protein kinase;phosphatases;Fmoc-chemistry;bis-TMS method
Issue Date: Jul-2006
Publisher: CSIR
IPC Code: Int.Cl.8 C07D
Abstract: The synthesis of new peptide fragment analog (Val-Tyr(P)-Val-Ala-Ala-OH) incorporating Tyr into the phosphorylation site of the cAMP protein kinase regulatory sub unit type II in place of Ser (Val-Ser(P)-Val-Ala-Ala-OH) has been described. The phosphopentapeptide fragment is prepared by Fmoc chemistry employing the global phosphorylation method. The yield (68%) as well as purity of the final peptide is satisfactory. The peptide is fully characterized by HPLC, NMR and mass spectral data.
Page(s): 1747-1752
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(07) [July 2006]

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