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Title: Antibacterial and antifungal studies on some new acetylcinnolines and cinnolinyl thiazole derivatives
Authors: Narayana, B
Raj, K K Vijaya
Ashalatha, B V
Kumari, N Suchetha
Keywords: Synthesis
cinnolinyl thiazole
antibacterial activity
antifungal activity
Issue Date: Jul-2006
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>8</sup> C07D</b>
Abstract: Synthesis of some new 3-acetylcinnolines <b style="">2a-d</b> has been carried out by the intramolecular cyclisation of phenylhydrazonoacetylacetone<b style=""> 1a-d</b>.<b style=""> </b>3-Acetyl-4,8-dimethylcinnoline <b style="">2b</b> has been converted to 3-(bromoacetyl)-4,8-dimethylcinnoline <b style="">3b</b>. The 3-(bromoacetyl)-4,8-dimethylcinnoline <b style="">3b</b> has then been treated with thioacetamide <b style="">4a</b>, thiourea <b style="">4b</b> and substituted thioureas <b style="">4c-f</b> in ethanol to get 4-(4,8-dimethylcinnolin-3-yl)-2-methyl-1,3-thiazole <b>5a</b>, 4-(4,8-dimethylcinnolin-3-yl)-2-amino-1,3-thiazole <b>5b</b><b style=""> </b>and N- (aryl)-4-(4,8-dimethylcinnolin-3-yl)-1,3-thiazol-2-amines <b style="">5c-f</b>. The newly synthesized compounds have been characterized by elemental analysis, IR, <sup>1</sup>H NMR and mass spectral studies. Compounds have been screened for their antifungal and antibacterial activity. 4,7-dimethyl-3-acetylcinnoline <b>2c</b> has emerged as a promising antibacterial agent and N-(3-chlorophenyl)-4-(4,8-dimethylcinnolin-3-yl)-1,3-thiazol-2-amine <b style="">5d</b> has emerged as a promising antifungal agent.
Description: 1704-1709
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(07) [July 2006]

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