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Title: Synthesis of some novel ethyl 5-methyl-6-cyano-7-substituted-2-oxo-2H-pyrano [2, 3-b] pyridine-3-carboxylate derivatives
Authors: Kumar, N Vasanth
Mashelker, Uday C
Keywords: Pyridine;pyridine-3-carboxylates;antihypertensive activity
Issue Date: Jul-2006
Publisher: CSIR
IPC Code: Int.Cl.8 C07D
Abstract: Ethyl 5-methyl-6-cyano-7-substituted-2-oxo-2H-pyrano[2, 3-b]pyridine-3-carboxylates 4a-j have been prepared starting from 2, 6-dihyroxy-3-cyano-4-methyl pyridine 1. The compound 1 reacts with N,N-dimethylaminoethylenemalonate in acetic acid under reflux conditions to give 5-methyl-6-cyano-7-hydroxy -2H-pyrano[2,3-b]pyridine-2-one 2, which is further treated with phosphorous oxychloride to obtain ethyl 5-methyl-6-cyano-7-chloro-2-oxo-2H-pyrano[2,3-b]pyridine-3-carboxylate 3. This chloride derivative 3 is finally converted to various amino derivatives 4a-j by condensation with corresponding amines. These compounds are expected to have antihypertensive activity.
Page(s): 1770-1773
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(07) [July 2006]

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