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Title: Synthesis of some novel ethyl 5-methyl-6-cyano-7-substituted-2-oxo-2<i>H</i>-pyrano [2, 3-<i>b</i>] pyridine-3-carboxylate derivatives
Authors: Kumar, N Vasanth
Mashelker, Uday C
Keywords: Pyridine
antihypertensive activity
Issue Date: Jul-2006
Publisher: CSIR
Series/Report no.: <b>Int.Cl.<sup>8</sup> C07D</b>
Abstract: Ethyl 5-methyl-6-cyano-7-substituted-2-oxo-2<i>H</i>-pyrano[2, 3-<i>b</i>]pyridine-3-carboxylates <b style="">4a-j</b> have been prepared starting from 2, 6-dihyroxy-3-cyano-4-methyl pyridine <b style="">1</b>. The compound <b style="">1</b> reacts with <i>N</i>,<i>N</i>-dimethylaminoethylenemalonate in acetic acid under reflux conditions to give 5-methyl-6-cyano-7-hydroxy -2<i>H</i>-pyrano[2,3-<i>b</i>]pyridine-2-one <b style="">2</b>, which is further treated with phosphorous oxychloride to obtain ethyl 5-methyl-6-cyano-7-chloro-2-oxo-2<i>H</i>-pyrano[2,3-<i>b</i>]pyridine-3-carboxylate<b style=""> 3</b>. This chloride derivative <b style="">3</b> is finally converted to various amino derivatives <b style="">4a-j</b> by condensation with corresponding amines. These compounds are expected to have antihypertensive activity.
Description: 1770-1773
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(07) [July 2006]

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