|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(07) [July 2006] >
| Title: | Synthesis of some novel ethyl 5-methyl-6-cyano-7-substituted-2-oxo-2H-pyrano [2, 3-b] pyridine-3-carboxylate derivatives |
| Authors: | Kumar, N Vasanth
Mashelker, Uday C |
| Keywords: | Pyridine
pyridine-3-carboxylates
antihypertensive activity |
| Issue Date: | Jul-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.8 C07D |
| Abstract: | Ethyl 5-methyl-6-cyano-7-substituted-2-oxo-2H-pyrano[2, 3-b]pyridine-3-carboxylates 4a-j have been prepared starting from 2, 6-dihyroxy-3-cyano-4-methyl pyridine 1. The compound 1 reacts with N,N-dimethylaminoethylenemalonate in acetic acid under reflux conditions to give 5-methyl-6-cyano-7-hydroxy -2H-pyrano[2,3-b]pyridine-2-one 2, which is further treated with phosphorous oxychloride to obtain ethyl 5-methyl-6-cyano-7-chloro-2-oxo-2H-pyrano[2,3-b]pyridine-3-carboxylate 3. This chloride derivative 3 is finally converted to various amino derivatives 4a-j by condensation with corresponding amines. These compounds are expected to have antihypertensive activity. |
| Page(s): | 1770-1773 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(07) [July 2006]
|
|
