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Title: Microwave assisted rapid and efficient synthesis of nitrogen and sulphur containing heterocyclic compounds and their pharmacological evaluation
Authors: Mistry, Ketan
Desai, K R
Keywords: Azetidinone
chloroacetyl chloride
thiolactic acid
microwave method
anti­bacterial activity
Issue Date: Jul-2006
Publisher: CSIR
Series/Report no.: <b>Int.Cl.<sup>8</sup>C07D</b>
Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="country-region"><smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place"> A series of compounds namely, 3-chloro-4-(2′′,4′′-dichlorophenyl)-4-methyl-1-(substituted-1′,3′-benzothiazol-2′-yl)-azetidin-2-ones <b style="">4a-j</b> and 2-(2′′,4′′-dichlorophenyl)-2,5-dimethyl-3-(substituted-1′,3′-benzothiazol-2′-yl)-1,3-thiazolidin-4-ones <b style="">5a-j</b> have been prepared by the reaction of schiff base derivatives <b style="">3 </b>with chloroacetyl chloride in the presence of triethylamine and thiolactic acid, respectively. The schiff base derivatives <b style="">3</b> have been prepared by the condensation of substituted-2-aminobenzothiazole <b style="">1</b> with 2,4-dichloroacetophenone <b style="">2</b>. The reactions have been carried out by microwave and conventional methods. The microwave assisted reactions are carried out in a “QPro-M modified microwave oven” made in Canada. Both the azetidinones and thiazolidinones are pharmacologically active and screened for their antibacterial activity against <i style="">Staphylococcus aureus, Bacillus subtilis, Escherichia coli </i>and<i style=""> Salmonella typhi </i>and antifungal activity against <i style="">Candida albicans</i>. </smarttagtype></smarttagtype>
Description: 1762-1766
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(07) [July 2006]

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