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Title: Microwave assisted rapid and efficient synthesis of nitrogen and sulphur containing heterocyclic compounds and their pharmacological evaluation
Authors: Mistry, Ketan
Desai, K R
Keywords: Azetidinone
chloroacetyl chloride
thiolactic acid
microwave method
anti­bacterial activity
Issue Date: Jul-2006
Publisher: CSIR
Series/Report no.: Int.Cl.8C07D
Abstract:  A series of compounds namely, 3-chloro-4-(2′′,4′′-dichlorophenyl)-4-methyl-1-(substituted-1′,3′-benzothiazol-2′-yl)-azetidin-2-ones 4a-j and 2-(2′′,4′′-dichlorophenyl)-2,5-dimethyl-3-(substituted-1′,3′-benzothiazol-2′-yl)-1,3-thiazolidin-4-ones 5a-j have been prepared by the reaction of schiff base derivatives 3 with chloroacetyl chloride in the presence of triethylamine and thiolactic acid, respectively. The schiff base derivatives 3 have been prepared by the condensation of substituted-2-aminobenzothiazole 1 with 2,4-dichloroacetophenone 2. The reactions have been carried out by microwave and conventional methods. The microwave assisted reactions are carried out in a “QPro-M modified microwave oven” made in Canada. Both the azetidinones and thiazolidinones are pharmacologically active and screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella typhi and antifungal activity against Candida albicans.
Description: 1762-1766
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(07) [July 2006]

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