Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6559
Title: Tri-iodo thyronine regulates antioxidant enzyme activities in different cell fractions through a mechanism sensitive to actinomycin D in a teleost, <i style="">Anabas testudineus</i> (Bloch)
Authors: Saumya, S M
Sreejith, P
Vijayasree, A S
Divya, L
Manju, M
Oommen, O V
Keywords: Actinomycin D
<i style="">Anabas</i>
Antioxidant enzymes
Fish
Lipid peroxidation
Liver
Teleost
Thyroid
Tri-iodothyronine
Issue Date: Aug-2006
Publisher: CSIR
Abstract: The present study evaluated the effects of hyperthyroid state on lipid peroxidation and antioxidant enzymes in the crude (CF), post nuclear (PNF) and mitochondrial fractions (MF) of the fish liver. The <i style="">in vivo</i> injection of T<sub>3</sub> (200ng) did not change the lipid peroxidation products, malondialdehyde (MDA) and conjugated dienes (CD), while actinomycin D (10mg), a potent mRNA inhibitor when administered with T<sub>3</sub> increased them. The antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) had an increased activity in CF and MF of hyperthyroid group to compete the increased oxidative stress, but actinomycin D partially inhibited the T<sub>3</sub>‑ &nbsp;induced activity. SOD and CAT activities in PNF of hyperthyroid group had no change, the glutathione concentration varied depending on the GPx and GR activity. Hyperthyroidism decreased the protein content, while simultaneous administration of actinomycin D inhibited the T<sub>3</sub> action of elevating the protein content. The results suggest that the antioxidant defense status in <i style="">A. testudineus</i> is modulated by thyroid hormone, through an action sensitive to actinomycin D.
Description: 640-646
URI: http://hdl.handle.net/123456789/6559
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(08) [August 2006]

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