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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(08) [August 2006] >
| Title: | Protective effect of Ocimum sanctum L after high-dose 131iodine exposure in mice:An in vivo study |
| Authors: | Bhartiya, Uma S
Raut, Yogita S
Joseph, Lebana J |
| Keywords: | Antioxidant enzymes
131Iodine
Mice
Ocimum sanctum
Radioprotection
Salivary gland |
| Issue Date: | Aug-2006 |
| Publisher: | CSIR |
| Abstract: | Radioprotective
effect of aqueous extract of Ocimum
sanctum (40 mg/kg body weight, for 15 days) in mice exposed to high-doses (3.7 MBq) of oral 131iodine
was investigated by studying the organ weights, lipid peroxidation and
antioxidant defense enzymes in various target organs like liver, kidneys,
salivary glands and stomach at 24 hr after exposure in adult Swiss mice. The
mean weight of the salivary glands showed significant increase after 131iodine
administration. 131iodine exposure significantly increased lipid
peroxidation in kidneys and salivary glands in comparison to control animals. Pretreatment
with O. sanctum in radioiodine
exposed group showed significant reduction in lipid peroxidation in both
kidneys and salivary glands. In liver, reduced glutathione (GSH) levels showed
significant reduction after radioiodine exposure while pretreatment with O. sanctum exhibited less depletion in
GSH level even after 131iodine exposure. However, no such changes
were observed in stomach. The results indicate the possibility of using aqueous
extract of O. sanctum for
ameliorating 131Iodine induced damage to the salivary glands. |
| Page(s): | 647-652 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(08) [August 2006]
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