Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6549
Title: Protective effect of <i style="">Ocimum sanctum </i>L after high-dose <sup>131</sup>iodine exposure in mice:An <i style="">in vivo</i> study
Authors: Bhartiya, Uma S
Raut, Yogita S
Joseph, Lebana J
Keywords: Antioxidant enzymes
<sup>131</sup>Iodine
Mice
<i style="">Ocimum sanctum</i>
Radioprotection
Salivary gland
Issue Date: Aug-2006
Publisher: CSIR
Abstract: Radioprotective effect of aqueous extract of <i style="">Ocimum sanctum </i>(40 mg/kg body weight, for 15 days)<i style=""> </i>in mice exposed to high-doses (3.7 MBq) of oral <sup>131</sup>iodine was investigated by studying the organ weights, lipid peroxidation and antioxidant defense enzymes in various target organs like liver, kidneys, salivary glands and stomach at 24 hr after exposure in adult Swiss mice. The mean weight of the salivary glands showed significant increase after <sup>131</sup>iodine administration. <sup>131</sup>iodine exposure significantly increased lipid peroxidation in kidneys and salivary glands in comparison to control animals. Pretreatment with <i style="">O. sanctum</i> in radioiodine exposed group showed significant reduction in lipid peroxidation in both kidneys and salivary glands. In liver, reduced glutathione (GSH) levels showed significant reduction after radioiodine exposure while pretreatment with <i style="">O. sanctum </i>exhibited less depletion in GSH level even after <sup>131</sup>iodine exposure. However, no such changes were observed in stomach. The results indicate the possibility of using aqueous extract of <i style="">O. sanctum</i> for ameliorating <sup>131</sup>Iodine induced damage to the salivary glands.
Description: 647-652
URI: http://hdl.handle.net/123456789/6549
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(08) [August 2006]

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