Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6547
Title: Erythrocyte antioxidant enzymes in toxicological evaluation of commonly used organophosphate pesticides
Authors: Singh, Mohan
Sandhir, Rajat
Kiran, Ravi
Keywords: Acetylcholinesterase
Erythrocytes
Glucose-6-phosphate dehydrogenase
Glutathione reductase
Glutathione-s-transferase
Issue Date: Jul-2006
Publisher: CSIR
Abstract: Erythrocytes are excellent models for the study of interactions of xenobiotics with biomembranes. Present work is designed to study the <i style="">in vitro</i> effects of some organophosphates (ethion, chlorpyrifos, dimethoate and monocrotophos) on rat erythrocytes. Treatment of erythrocytes with organophosphates resulted in decreased erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity, whereas activities of glutathione-s-transferase (GST) and glutathione reductase (GR) were increased. Reduced Glutathione (GSH) content of RBCs was decreased after treatment with the pesticides. Increased activities of GST and GR were due to induction of natural defense mechanism of erythrocytes against the toxicity of the pesticides. Membrane bound enzymes like acetylcholinesterase (AChE), Na<sup>+</sup>-K<sup>+</sup>-ATPase and Ca<sup>2+</sup>-ATPase were also inhibited. Altered activities of these enzymes along with decreased GSH content indicate increased oxidative stress in erythrocytes after treatment with organophosphates
Description: 580-583
URI: http://hdl.handle.net/123456789/6547
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(07) [July 2006]

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