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Title: Erythrocyte antioxidant enzymes in toxicological evaluation of commonly used organophosphate pesticides
Authors: Singh, Mohan
Sandhir, Rajat
Kiran, Ravi
Keywords: Acetylcholinesterase;Erythrocytes;Glucose-6-phosphate dehydrogenase;Glutathione reductase;Glutathione-s-transferase
Issue Date: Jul-2006
Publisher: CSIR
Abstract: Erythrocytes are excellent models for the study of interactions of xenobiotics with biomembranes. Present work is designed to study the in vitro effects of some organophosphates (ethion, chlorpyrifos, dimethoate and monocrotophos) on rat erythrocytes. Treatment of erythrocytes with organophosphates resulted in decreased erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity, whereas activities of glutathione-s-transferase (GST) and glutathione reductase (GR) were increased. Reduced Glutathione (GSH) content of RBCs was decreased after treatment with the pesticides. Increased activities of GST and GR were due to induction of natural defense mechanism of erythrocytes against the toxicity of the pesticides. Membrane bound enzymes like acetylcholinesterase (AChE), Na+-K+-ATPase and Ca2+-ATPase were also inhibited. Altered activities of these enzymes along with decreased GSH content indicate increased oxidative stress in erythrocytes after treatment with organophosphates
Page(s): 580-583
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(07) [July 2006]

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