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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(07) [July 2006] >
| Title: | Erythrocyte antioxidant enzymes in toxicological evaluation of commonly used organophosphate pesticides |
| Authors: | Singh, Mohan
Sandhir, Rajat
Kiran, Ravi |
| Keywords: | Acetylcholinesterase
Erythrocytes
Glucose-6-phosphate dehydrogenase
Glutathione reductase
Glutathione-s-transferase |
| Issue Date: | Jul-2006 |
| Publisher: | CSIR |
| Abstract: | Erythrocytes
are excellent models for the study of interactions of xenobiotics with
biomembranes. Present work is designed to study the in vitro effects of some organophosphates (ethion, chlorpyrifos,
dimethoate and monocrotophos) on rat erythrocytes. Treatment of erythrocytes
with organophosphates resulted in decreased erythrocyte glucose-6-phosphate
dehydrogenase (G-6-PD) activity, whereas activities of
glutathione-s-transferase (GST) and glutathione reductase (GR) were increased.
Reduced Glutathione (GSH) content of RBCs was decreased after treatment with
the pesticides. Increased activities of GST and GR were due to induction of
natural defense mechanism of erythrocytes against the toxicity of the
pesticides. Membrane bound enzymes like acetylcholinesterase (AChE), Na+-K+-ATPase
and Ca2+-ATPase were also inhibited. Altered activities of these
enzymes along with decreased GSH content indicate increased oxidative stress in
erythrocytes after treatment with organophosphates |
| Page(s): | 580-583 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(07) [July 2006]
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