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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(07) [July 2006] >
| Title: | Teratogenicity of Asparagus racemosus Willd. root, a herbal medicine |
| Authors: | Goel, R K
Prabha, T
Kumar, M Mohan
Dorababu, M
Prakash
Singh, G |
| Keywords: | Asparagus racemosus
Herbal medicines
Satavari
Teratogenicity |
| Issue Date: | Jul-2006 |
| Publisher: | CSIR |
| Abstract: | Asparagus racemosus (AR) is a herb used as a rasayana in Ayurveda
and is considered both general and female reproductive tonic. Methanolic
extract of A. racemosus roots (ARM;
100 mg/kg/day for 60 days) showed teratological disorders in terms of increased
resorption of fetuses, gross malformations e.g. swelling in legs and
intrauterine growth retardation with a small placental size in Charles Foster
rats. Pups born to mother exposed to ARM for full duration of gestation showed
evidence of higher rate of resorption and therefore smaller litter size. The
live pup showed significant decrease in body weight and length and delay of
various developmental parameters when compared to respective control groups. AR
therefore, should be used in pregnancy cautiously as its exposure during that
period may cause damage to the offspring. |
| Page(s): | 570-573 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(07) [July 2006]
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