NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(07) [July 2006] >

Title: A comparative study on the protective effects of 17β-estradiol, biochanin A and bisphenol A on mammary gland differentiation and tumorigenesis in rats
Authors: Yin, Hong
Ito, Akihiro
Bhattacharjee, Dilip
Hoshi, Masaharu
Keywords: Biochanin A
Bisphenol A
Mammary gland differentiation
Mammary tumorigenesis
Issue Date: Jul-2006
Publisher: CSIR
Abstract: Mammary tissue differentiation and tumorigenesis were studied in female rats following subcutaneous injection at 2, 4 and 6 days after birth with low or high doses of 17β-estradiol (0.1 or 10 µg; E2), biochanin A (0.1 or 10 mg; BCA) or bisphenol A (0.1 or 10.0 mg; BPA). Half of the rats were killed on day 35 to analyze the terminal end bud (TEB), terminal duct (TD) and alveolar bud (AB) of the mammary tissue. The remaining rats were injected, ip, with a dose of 50 mg/kg of N-nitroso-N-methylurea (MNU) at 7 weeks of age and sacrificed 26 weeks later. The incidence and multiplicity of mammary tumors (MT) decreased among all three different treated groups, dose-dependently. However, the pattern of mammary gland differentiation varied. No significant difference was observed after E2 administration. TEB decreased dose-dependently in BCA treated groups and the number of TD and AB were suppressed significantly in BPA high dose group.
Page(s): 540-546
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(07) [July 2006]

Files in This Item:

File Description SizeFormat
IJEB 44(7) 540-546.pdf908.95 kBAdobe PDFView/Open
 Current Page Visits: 62 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 165293 since 01-Sep-2015  Last updated on 27-Jun-2016Webmaster: