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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(07) [July 2006] >
| Title: | Resveratrol, a polyphenolic phytoalexin attenuates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rats |
| Authors: | Sharma, Sameer
Kulkarni, S K
Chopra, Kanwaljit |
| Keywords: | Diabetic neuropathy
Hyperalgesia
Oxidative stress
Resveratrol |
| Issue Date: | Jul-2006 |
| Publisher: | CSIR |
| Abstract: | The effects of
resveratrol, a polyphenolic phytoalexin present in red wine have been
investigated on hyperalgesia and cold allodynia in streptozotocin (STZ) induced
diabetic rats. Diabetes was induced by a single intraperitoneal injection of
streptozotocin (65mg/kg). After 4-weeks of STZ injection, diabetic rats
exhibited a significant thermal hyperalgesia and cold allodynia along with
increased plasma glucose and decreased body weights as compared with controls
rats. Chronic treatment with resveratrol (10mg/kg orally) from week 4 to week 6
significantly attenuated the cold allodynia and thermal hyperalgesia. The
results emphasize the role of oxidative stress in development of hyperalgesia
and cold allodynia in diabetic animals and point towards the potential of
resveratrol as an adjuvant therapy for the prevention and treatment of diabetic
neuropathy. |
| Page(s): | 566-569 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(07) [July 2006]
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