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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(07) [July 2006] >
| Title: | Evaluation of adaptogenic activity profile of herbal preparation |
| Authors: | Azmathulla, Shaik
Hule, Amolkumar
Naik, Suresh Ramnath |
| Keywords: | Adaptogenic
Antistress
Anabolic
Immunomodulatory
Haematological parameters |
| Issue Date: | Jul-2006 |
| Publisher: | CSIR |
| Abstract: | The herbal formulation, AVM is a proprietary
formula that consists of extracts of herbs that have been used in Indian
traditional medicine to promote physical and mental health, improve defense
mechanisms of the body and enhance longevity. AVM (500 and 1000 mg/kg) was
tested for its adaptogenic activity by determining antistress, anabolic and
immunomodulatory effects. In antistress activity, pretreatment with AVM
significantly attenuated the changes in ascorbic acid (from blood and adrenal),
cortisol (from plasma and adrenal) and adrenal gland weights induced due to
restrain stress (physical immobilization). Its antistress effect at 1000 mg/kg
was comparable to that of diazepam (5 mg/kg) treated group. Leucopenia, and
anemia induced by cyclophosphamide (CYP) was shown to reduce significantly by
AVM. Treatment of AVM + CYP had increased spleen and thymus weights
significantly as compared to CYP alone treated group. The anabolic activity was
evaluated by weight gain of the levator ani muscle, ventral prostrate gland and
seminal vesicles in rats as compared to untreated control. |
| Page(s): | 574-579 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(07) [July 2006]
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