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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(04) [April 2007] >
| Title: | Synthesis and antimicrobial activity of novel linearly fused 5-substituted- 7-acetyl-2,6-dimethyloxazolo [4,5-f]indoles |
| Authors: | Donawade, Dundappa S
Raghu, A V
Gadaginamath, Guru S |
| Keywords: | Indoles
Hydroxylamine
Mono-oximes
Antibacterial activity
Antifungal activity |
| Issue Date: | Apr-2007 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl. ⁸ C07D |
| Abstract: | The exclusive formation of 1-substituted-6-⍺-oximinoethylindoles 3a-d from the reaction of 3,6-diacetylindoles with hydroxylamine reveals the chemoselectivity of C₆-acetyl function over that of C₃-acetyl function towards the nucleophilic attack of hydroxylamine. These monooximes 3a-d are stirred with methanesulphonyl chloride in dry pyridine at room temperature to give the novel 5-substituted-7-acetyl-3,6- dimethyloxazolo[4,5-f]indoles 5a-d in good yields. The structures of all these newly synthesised compounds have been confirmed by their spectral and analytical data and they have been screened for antibacterial and antifungal activities. |
| Page(s): | 690-693 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(04) [April 2007]
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