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IJC-B Vol.46B [2007] >
IJC-B Vol.46B(04) [April 2007] >


Title: Synthesis and antimicrobial activity of novel linearly fused 5-substituted- 7-acetyl-2,6-dimethyloxazolo [4,5-f]indoles
Authors: Donawade, Dundappa S
Raghu, A V
Gadaginamath, Guru S
Keywords: Indoles
Hydroxylamine
Mono-oximes
Antibacterial activity
Antifungal activity
Issue Date: Apr-2007
Publisher: CSIR
IPC CodeInt. Cl. ⁸ C07D
Abstract: The exclusive formation of 1-substituted-6-⍺-oximinoethylindoles 3a-d from the reaction of 3,6-diacetylindoles with hydroxylamine reveals the chemoselectivity of C₆-acetyl function over that of C₃-acetyl function towards the nucleophilic attack of hydroxylamine. These monooximes 3a-d are stirred with methanesulphonyl chloride in dry pyridine at room temperature to give the novel 5-substituted-7-acetyl-3,6- dimethyloxazolo[4,5-f]indoles 5a-d in good yields. The structures of all these newly synthesised compounds have been confirmed by their spectral and analytical data and they have been screened for antibacterial and antifungal activities.
Page(s): 690-693
ISSN: 0376-4699
Source:IJC-B Vol.46B(04) [April 2007]

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