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IJEB Vol.44(07) [July 2006] >


Title: Characteristics and physiological role of surfactant-like particles secreted by entrocytes
Authors: Turan, Aasma
Gupta, Shiffalli
Mahmood, Akhtar
Keywords: Fat feeding
Intestinal lumen
Surfactant-like particles
Issue Date: Jul-2006
Publisher: CSIR
Abstract: Intestinal epithelium secretes novel unilamellar membranes having characteristics similar to lung surfactants and thus has been named Surfactant-like particles (SLP). The chemical analysis of the membranes revealed cholesterol/phospholipid molar ratio of 0.68-0.78, which is much distinct from that of the underlying microvillus membranes (1.34-1.49). The membrane contains 4-6 proteins with a molar weight of 30-120 kDa and is enriched with alkaline phosphatase, contains low amounts of disaccharidases but no Na+, K+–ATPase activity. The secretion of SLP is stimulated by fat feeding. Chronic ethanol ingestion also induces the formation of SLP in rat intestine. A number of physiological functions have been attributed to SLP, which include: (i) as a protective lubricant in intestinal lumen, (ii) a role in triacylglycerol transport, (iii) as a vehicle for the transport of luminal proteins into blood, (iv) as a stratum for the adhesion of microorganisms in intestinal lumen, and (v) a role in trans-signalling mechanism across the basolateral surface of enterocytes.
Page(s): 519-525
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(07) [July 2006]

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