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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(07) [July 2006] >
| Title: | Characteristics and physiological role of surfactant-like particles secreted by entrocytes |
| Authors: | Turan, Aasma
Gupta, Shiffalli
Mahmood, Akhtar |
| Keywords: | Fat feeding
Intestinal lumen
Surfactant-like particles |
| Issue Date: | Jul-2006 |
| Publisher: | CSIR |
| Abstract: | Intestinal epithelium secretes novel unilamellar
membranes having characteristics similar to lung surfactants and thus has been
named Surfactant-like particles (SLP). The chemical analysis of the membranes
revealed cholesterol/phospholipid molar ratio of 0.68-0.78, which is much
distinct from that of the underlying microvillus membranes (1.34-1.49). The
membrane contains 4-6 proteins with a molar weight of 30-120 kDa and is
enriched with alkaline phosphatase, contains low amounts of disaccharidases but
no Na+, K+–ATPase activity. The secretion of SLP is stimulated by fat feeding.
Chronic ethanol ingestion also induces the formation of SLP in rat intestine. A
number of physiological functions have been attributed to SLP, which include:
(i) as a protective lubricant in intestinal lumen, (ii) a role in
triacylglycerol transport, (iii) as a vehicle for the transport of luminal
proteins into blood, (iv) as a stratum for the adhesion of microorganisms in
intestinal lumen, and (v) a role in trans-signalling mechanism across the
basolateral surface of enterocytes. |
| Page(s): | 519-525 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(07) [July 2006]
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