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Title: Positive inotropic effect of Murraya koenigii (Linn.) Spreng extract on an isolated perfused frog heart
Authors: Shah, Kunal J
Juvekar, Archana R
Keywords: Frog heart
Murraya koenigii
Positive inotropic effect
Issue Date: Jun-2006
Publisher: CSIR
Abstract: Ethanolic extract of fresh leaves of M. koenigii (MKEE) showed a dose dependent positive inotropic effect on isolated frog heart. The responses to MKEE (62.5–1000 mg) were not affected in either way by theophylline, imidazole, propranolol and sildenafil. The change in potassium and sodium concentration did not alter MKEE-induced positive inotropic effect. Lignocaine did not alter the responses to MKEE significantly. Responses to MKEE were significantly inhibited when calcium concentration was reduced to half (from 1.58 to 0.79 mM) and were significantly potentiated when calcium concentration was doubled (from 1.58 to 3.16 mM). Verapamil was found to inhibit the responses significantly. The results suggest that M. koenigii induced positive inotropic effect possibly by increasing availability of calcium from extra cellular sites.
Page(s): 481-484
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(06) [June 2006]

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