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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(06) [June 2006] >
| Title: | Antioxidant and anti-inflammatory activity of extract obtained from Aspergillus candidus MTCC 2202 broth filtrate |
| Authors: | Malpure, Pankaj P
Shah, Abhishek S
Juvekar, Archana R |
| Keywords: | Anti-inflammatory activity
Antioxidant activity
Aspergillus candidus
Phenolic compound
Reducing power |
| Issue Date: | Jun-2006 |
| Publisher: | CSIR |
| Abstract: | Antioxidant potential of Aspergillus candidus MTCC 2202 broth
filtrate extract was studied using different antioxidant models, whereas
anti-inflammatory potential was studied using carrageenan-induced rat paw
oedema model. The ethyl acetate extract at 1000 µg/ml showed maximum scavenging
activity of the stable radical 1,1-diphenyl,2-picryl hydrazyl upto 96.65% (IC50=430.36
µg/ml) and scavenging of the radical cation,
2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonate) upto 92.25% (IC50=606.29
µg/ml) at the same concentration. The extract had good reducing power, however
showed moderate inhibition for conjugated dienes and thiobarbituric acid
reactive acid substances (59.56 and 51.45%). The total phenolic content of
various extracts of A. candidus broth
filtrate was measured and a correlation between radical scavenging activities
of extracts with total phenolic content was observed. The ethyl acetate extract
(125 mg/kg ip) showed significant anti-inflammatory activity in
carrageenan-induced rat paw oedema model. The exhibited antioxidant activity of
ethyl acetate extract of A. candidus
broth filtrate was comparable with BHA and ascorbic acid, while anti-inflammatory
activity was comparable with standard diclofenac sodium. |
| Page(s): | 468-473 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(06) [June 2006]
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