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Title: Synthesis and biological activities of new 7-<i style="">o</i>-<img src='/image/spc_char/beta.gif' border=0>-D-glucopyranosyloxy-3-(3-oxo-3-arylprop-1-enyl)-chromones
Authors: Hatzade, K M
Taile, V S
Gaidhane, P K
Umare, V D
Haldar, A G M
Ingle, V N
Keywords: Chromones
<img src='/image/spc_char/alpha.gif' border=0>,<img src='/image/spc_char/beta.gif' border=0>-unsaturated carbonyl compounds
<i>o</i>-<img src='/image/spc_char/beta.gif' border=0>-D-glucosides
biological activity
Issue Date: Nov-2009
Publisher: CSIR
Abstract: A convenient route to synthesize some new medicinally important 7-hydroxy-3-(3-oxo-3-arylprop-1-enyl)-chromones<b style=""> 2</b> is described by the interaction of 7-hydroxy-3-formyl chromone <b style="">1</b> with various substituted acetophenones which on condensation with 2,3,4,6-tetra-<i style="">o</i>-acetyl-<img src='/image/spc_char/alpha.gif' border=0>-D-glucopyranosyl bromide affords 2,3,4,6-tetra-<i style="">o</i>-acetyl-<img src='/image/spc_char/beta.gif' border=0>-D-glucopyranosyloxy-3-(3-oxo-3-arylprop-1-enyl)-4<i style="">H</i>-chromen-4-ones <b style="">3</b>. Later on deacetylation with anhydrous zinc acetate in methanol gives 7-<i style="">o</i>-<img src='/image/spc_char/beta.gif' border=0>-D-glucopyranosyloxy-3-(3-oxo-3-arylprop-1-enyl)-4<i style="">H</i>-chromen-4-ones <b style="">4</b>. These compounds are evaluated for their <i style="">in vitro</i> antimicrobial and antioxidant activity. The structures of these newly synthesized compounds are established by IR, NMR, mass spectra, elemental analysis and chemical analysis.
Description: 1548-1557
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.48B(11) [November 2009]

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