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IJC-B Vol.48B(11) [November 2009] >

Title: Synthesis and biological activities of new 7-o--D-glucopyranosyloxy-3-(3-oxo-3-arylprop-1-enyl)-chromones
Authors: Hatzade, K M
Taile, V S
Gaidhane, P K
Umare, V D
Haldar, A G M
Ingle, V N
Keywords: Chromones
,-unsaturated carbonyl compounds
biological activity
Issue Date: Nov-2009
Publisher: CSIR
Abstract: A convenient route to synthesize some new medicinally important 7-hydroxy-3-(3-oxo-3-arylprop-1-enyl)-chromones 2 is described by the interaction of 7-hydroxy-3-formyl chromone 1 with various substituted acetophenones which on condensation with 2,3,4,6-tetra-o-acetyl--D-glucopyranosyl bromide affords 2,3,4,6-tetra-o-acetyl--D-glucopyranosyloxy-3-(3-oxo-3-arylprop-1-enyl)-4H-chromen-4-ones 3. Later on deacetylation with anhydrous zinc acetate in methanol gives 7-o--D-glucopyranosyloxy-3-(3-oxo-3-arylprop-1-enyl)-4H-chromen-4-ones 4. These compounds are evaluated for their in vitro antimicrobial and antioxidant activity. The structures of these newly synthesized compounds are established by IR, NMR, mass spectra, elemental analysis and chemical analysis.
Page(s): 1548-1557
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.48B(11) [November 2009]

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