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IJC-B Vol.48B [2009] >
IJC-B Vol.48B(11) [November 2009] >


Title: Study on characterization and degree of esterification of styrene maleic anhydride by some medicines
Authors: Rajput, Ravish Singh
Rupainwar, D C
Singh, Rama Kant
Singh, Amarika
Keywords: Esterification
polymeric prodrug
polymer conjugation
styrene-co-maleic anhydride
hydrolyzing reaction
Issue Date: Nov-2009
Publisher: CSIR
Abstract: Styrene-co-maleic anhydride has been used for the preparation of chemically and diffusionaly controlled polymeric prodrugs poly(styrene-co-maleic anhydride) conjugates with phenol based medicinal natural products like 2-methoxy-4-(2-propenyl)-phenol (eugenol) and synthetic o-hydroxy benzoic acid (salicylic acid) etc. in acetone and dioxane. The hydrolytic and binding behavior of the phenol based medicine was compared with the degree of esterification. 2-Methoxy-4-(2-propenyl)-phenol and o-hydroxy benzoic acid have low binding with styrene-co-maleic anhydride while other has good binding with styrene-co-maleic anhydride.
Page(s): 1597-1600
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.48B(11) [November 2009]

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