NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(11) [November 2009] >

Title: Synthesis of phthalimido or succinimido-[2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl)ethyl}amino]-1,3-thiazolidin-5-yl]ethanoate and their antimicrobial activities
Authors: Salvi, Vijay Kumar
Sharma, Shweta
Sharma, Chirag
Bhambi, Dinesh
Talesara, G L
Keywords: N-Hydroxysuccinimide
antimicrobial activity
Issue Date: Nov-2009
Publisher: CSIR
Abstract: Keeping in view the pharmacological potential of thiazolidinones and phenothiazines, the title compounds containing these nuclei have been synthesized. Reaction of 10-(chloroacetyl)phenothiazine 1 with hydrazine hydrate gives 10-(hydrazinoacetyl)phenothiazine 2, which on treatment with various aromatic aldehydes yields 10-[4-(arylidene)hydrazino acetyl] phenothiazine 3a-d. These Schiff bases 3a-d underwent cyclization when treated with mercaptosuccinic acid in presence of anhydrous zinc chloride to give [2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl)ethyl}amino]-1,3-thiazolidin-5-yl]ethanoic acid 4a-d, which are converted to [2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl)ethyl}amino]-1,3-thiazolidin-5-yl] ethanoyl chloride 5a-d on reaction with thionyl chloride. Subsequent treatment of 5a-d with N-hydroxyphthalimide or N-hydroxysuccinimide furnished phthalimido or succinimido-[2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl)ethyl}amino]-1,3-thiazolidin-5-yl]ethanoate 6a-h. The constitution of all the above products have been supported by elemental analysis and spectral studies. Antibacterial and antifungal activities of the final compounds have been evaluated and all the compounds have shown significant inhibition of bacterial and fungal growth.
Page(s): 1583-1589
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.48B(11) [November 2009]

Files in This Item:

File Description SizeFormat
IJCB 48B(11) 1583-1589.pdf126.18 kBAdobe PDFView/Open
 Current Page Visits: 97 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 165785 since 01-Sep-2015  Last updated on 27-Jun-2016Webmaster: