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Title: Microwave and conventional techniques for the synthesis of a series of pyrazolo [5,4-d]­pyri­midine derivatives and their antimicrobial screening
Authors: Rana, P B
Patel, J A
Mistry, B D
Desai, K R
Keywords: s-Triazine;pyrazolo[5,4-d]pyrimidine;anti­micro­bial activity;microwave techniques;spectral data
Issue Date: Nov-2009
Publisher: CSIR
Abstract: 1-{4′-[(4′′-6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))amino]phenyl}-3-methyl-4-(substituted phenyl)-4,5-dihydropyrazolo[5,4-d]pyri­mi­din-6-ol 4I-XXX and 1-{4′-[(4′′-6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))­amino]­phenyl}-3-methyl-4-(substituted phenyl)-4,5-dihydro­pyra­zolo[5,4-d]pyrimidin-6-thiol 5 I-XXX have been synthesized by the reaction of 1-{4′-[(4′′,6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))amino]­phenyl}-3-methyl-2-pyrazolin-5-one 3, with urea and various substituted aldehyde and with thiourea and various substituted aldehyde respectively. Both the reactions have been carried out by both the conventional and microwave techniques. It is noteworthy that the reaction which requires 6 hr in conventional method is completed within 3-4 min by microwave irradiation technique. The compounds have been screened for their antimicrobial activity against different micro-organisms. All the compounds show moderate to good activity against different micro-organisms at 256 µg/mL. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR and mass spectral data.
Page(s): 1601-1608
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.48B(11) [November 2009]

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