NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(11) [November 2009] >


Title: Microwave and conventional techniques for the synthesis of a series of pyrazolo [5,4-d]­pyri­midine derivatives and their antimicrobial screening
Authors: Rana, P B
Patel, J A
Mistry, B D
Desai, K R
Keywords: s-Triazine
pyrazolo[5,4-d]pyrimidine
anti­micro­bial activity
microwave techniques
spectral data
Issue Date: Nov-2009
Publisher: CSIR
Abstract: 1-{4′-[(4′′-6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))amino]phenyl}-3-methyl-4-(substituted phenyl)-4,5-dihydropyrazolo[5,4-d]pyri­mi­din-6-ol 4I-XXX and 1-{4′-[(4′′-6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))­amino]­phenyl}-3-methyl-4-(substituted phenyl)-4,5-dihydro­pyra­zolo[5,4-d]pyrimidin-6-thiol 5 I-XXX have been synthesized by the reaction of 1-{4′-[(4′′,6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))amino]­phenyl}-3-methyl-2-pyrazolin-5-one 3, with urea and various substituted aldehyde and with thiourea and various substituted aldehyde respectively. Both the reactions have been carried out by both the conventional and microwave techniques. It is noteworthy that the reaction which requires 6 hr in conventional method is completed within 3-4 min by microwave irradiation technique. The compounds have been screened for their antimicrobial activity against different micro-organisms. All the compounds show moderate to good activity against different micro-organisms at 256 µg/mL. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR and mass spectral data.
Page(s): 1601-1608
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.48B(11) [November 2009]

Files in This Item:

File Description SizeFormat
IJCB 48B(11) 1601-1608.pdf157.57 kBAdobe PDFView/Open
 Current Page Visits: 648 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 509942 since 06-Feb-2009  Last updated on 11-Apr-2014Webmaster: nopr@niscair.res.in