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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(11) [November 2009] >
| Title: | Microwave and conventional techniques for the synthesis of a series of pyrazolo [5,4-d]pyrimidine derivatives and their antimicrobial screening |
| Authors: | Rana, P B
Patel, J A
Mistry, B D
Desai, K R |
| Keywords: | s-Triazine
pyrazolo[5,4-d]pyrimidine
antimicrobial activity
microwave techniques
spectral data |
| Issue Date: | Nov-2009 |
| Publisher: | CSIR |
| Abstract: | 1-{4′-[(4′′-6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))amino]phenyl}-3-methyl-4-(substituted phenyl)-4,5-dihydropyrazolo[5,4-d]pyrimidin-6-ol 4I-XXX and 1-{4′-[(4′′-6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))amino]phenyl}-3-methyl-4-(substituted phenyl)-4,5-dihydropyrazolo[5,4-d]pyrimidin-6-thiol 5 I-XXX have been synthesized by the reaction of 1-{4′-[(4′′,6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))amino]phenyl}-3-methyl-2-pyrazolin-5-one 3, with urea and various substituted aldehyde and with thiourea and various substituted aldehyde respectively. Both the reactions have been carried out by both the conventional and microwave techniques. It is noteworthy that the reaction which requires 6 hr in conventional method is completed within 3-4 min by microwave irradiation technique. The compounds have been screened for their antimicrobial activity against different micro-organisms. All the compounds show moderate to good activity against different micro-organisms at 256 µg/mL. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR and mass spectral data. |
| Page(s): | 1601-1608 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.48B(11) [November 2009]
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