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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(11) [November 2009] >
| Title: | Spectral and single crystal X-ray structure of 4-(4′-methyl) benzylidene amino-5-phenyl-3-mercapto-1,2,4-triazole and its antimicrobial activity |
| Authors: | Begum, Aliya
Aparna, A V
Sireesha, B
Devi, Ch Sarala
Raghavaiah, Pallepogu |
| Keywords: | 4-(4′-Methyl) benzylidene amino-5-phenyl-3-mercapto-1,2,4-triazole
equilibrium studies
hydrogen bonding
antimicrobial activity |
| Issue Date: | Nov-2009 |
| Publisher: | CSIR |
| Abstract: | 4-(4′-Methyl) benzylidene amino-5-phenyl-3-mercapto-1,2,4-triazole (MBPMT) has been synthesized and characterized by elemental analyses, IR, UV, 1H and 13C NMR, DEPT, mass and XRD studies. The study of single crystal X-ray diffraction pattern of 4-(4′-methyl) benzylidene amino-5-phenyl-3-mercapto-1,2,4-triazole (MBPMT) reveals the presence of N—H· · ·S and C—H· · ·S intermolecular hydrogen bonding interactions. Equilibrium studies have been carried out with the MBPMT to determine the dissociation constant in 70% v/v dioxan-water medium at 303 K and 0.1 M (KNO3) ionic strength which indicate the presence of one dissociable proton corresponding to thiol group. The antimicrobial activity of MBPMT in DMSO medium is also assessed. |
| Page(s): | 1565-1570 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.48B(11) [November 2009]
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