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Title: Synthesis and antimicrobial screening of 4H-2-acetyl-3-acetyamido furo[3,2-c] benzopyran 4-one, 11H -2,4-dimethyl-3,4-dihydro-3-amino-4-hydroxy-pyrimido [3,2-d]furo [3,2-c] benzopyran-11-one and 4H-2-acetyl-3-(3´-methyl-1´,2´,4´-triazol-4´-yl) furo[3,2-c] benzopyran 4-one
Authors: Mulwad, V V
Hegde, A S
Keywords: Acetyl chloride
formic acid
hydrazine hydrate
antimicrobial activity
Issue Date: Nov-2009
Publisher: CSIR
Abstract:  A suspension of 4H-2-acetyl-3-amino furo [3,2-c] benzopyran 4-one 5a-d in aqueous sodium hydroxide is treated with acetyl chloride to give 4H-2-acetyl-3-acetylamido furo[3,2-c] benzopyran 4-one 6a-d. The compounds 6a-d and hydrazine hydrate in absolute alcohol is refluxed to give 11H-2,4-dimethyl-3,4-dihydro-3-amino-4-hydroxy-pyrimido[3,2-d] furo [3,2-c]benzopyran-11-one 7a-d which in formic acid is refluxed for 5 hr to give 4H-2-acetyl-3-(3´-methyl-1´,2´,4´-triazol-4´-yl) furo[3,2-c] benzopyran 4-one 8a-d. The structures of all these compounds have been established on the basis of the spectral and analytical data. All compounds have showed good antimicrobial activity.
Description: 1558-1564
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.48B(11) [November 2009]

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