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Title: Secretory factors of human neuroblastoma (IMR-32) and human glioblastoma (U87MG) cell lines induce neurite outgrowths in PC12 cells
Authors: Satpute, Ravindra M
Kashyap, Rajpal S
Kainthla, Rani Poonam
Purohit, Hemant J
Taori, Girdhar M
Daginawala, Hatim F
Keywords: Conditioned medium
Issue Date: May-2006
Publisher: CSIR
Abstract: Neurite outgrowth is essential for the communication of the nervous system. The rat Pheochromocytoma (PC12) cells are commonly used in the neuronal cell study. It is well known that exogenous stimuli such as Nerve Growth Factor (NGF) induce neurite outgrowth. In the present study it has been investigated whether or not the conditioned medium from human neuroblastoma cell line (IMR-32) and human glioblastoma cell line (U87MG) may augment neurite outgrowth in PC12 cells. PC12 were cultured with and without conditioned media of IMR-32 and U87MG. The result showed that both the conditioned media induce neurite outgrowth within 48 hr and stops further proliferation of PC12 cells. However no outgrowth was noted in PC12 cells incubated without conditioned medium. In conclusion, it is shown that both the conditioned media (IMR-32 and U87MG) have the potential to induce the neurite outgrowth in the PC12 cells.
Page(s): 367-370
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(05) [May 2006]

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