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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(05) [May 2006] >
| Title: | Nanotechnology based drug delivery system(s) for the management of tuberculosis |
| Authors: | Pandey, Rajesh
Khuller, G K |
| Keywords: | Alginate
Liposomes Nanoparticles
Poly lactide-co-glycolide
Tuberculosis |
| Issue Date: | May-2006 |
| Publisher: | CSIR |
| Abstract: | The era of nanotechnology has allowed new research strategies
to flourish in the field of drug delivery. Nanoparticle-based drug delivery
systems are suitable for targeting chronic intracellular infections such as
tuberculosis. Polymeric nanoparticles employing poly lactide-co-glycolide have shown
promise as far as intermittent chemotherapy in experimental tuberculosis is
concerned. It has distinct advantages over the more traditional drug carriers,
i.e. liposomes and microparticles. Although the experience with natural
carriers, e.g. solid lipid nanoparticles and alginate nanoparticles is in its
infancy, future research may rely heavily on these carrier systems. Given the
options for oral as well as parenteral therapy, the very nature of the disease
and its complex treatment urges one to emphasize on the oral route for
controlled drug delivery. Pending the discovery of more potent antitubercular
drugs, nanotechnology-based intermittent chemotherapy provides a novel and
sound platform for an onslaught against tuberculosis. |
| Page(s): | 357-366 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(05) [May 2006]
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