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IJC-B Vol.46B(06) [June 2007] >

Title: 3D-QSAR analysis of cycloguanil derivatives, highly active agents against A16V + S108T mutant of dihydrofolate reductase resistant strain (T9/94) of Plasmodium falciparum
Authors: Singh, Vineet
Tiwari, Meena
Keywords: 3D-QSAR
Plasmodium falciparum
Dihydrofolate reductase
A16V + S108T mutant
Multiple regression analysis
Issue Date: Jun-2007
Publisher: CSIR
Abstract: 3D-Quantitative-structure activity relationship of some 4,6-diamino-1,2-dihydrotriazine derivatives (cycloguanils) having good activity against resistant strain of P. falciparum has been performed. The model developed has shown that the descriptors, ovality (steric descriptor), dipole-dipole energy (thermodynamic descriptor) contributing positively while stretch bend energy (thermodynamic descriptor) negatively to the biological activity. Statistical analysis has shown the model to be fit (R=0.924, R²=0.853, F-test=18.840, t-test=4.340, stdev = 0.244, variance=0.051) and predictable (R²ւօօ=0.693, R²pred=0.265). It can be concluded that parent nuclei having functional groups with optimum values for these descriptors, might have better biological activity against resistant strains.
Page(s): 1042-1046
ISSN: 0376-4699
Source:IJC-B Vol.46B(06) [June 2007]

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