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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(05) [May 2006] >
| Title: | Comparative evaluation of possible ocular photochemical toxicity of fluoroquinolones meant for ocular use in experimental models |
| Authors: | Velpandian, T
Bankoti, R
Humayun, S
Ravi, A K
Kumari, S S
Biswas, N R |
| Keywords: | Bovine vitreous
Eye
Fluoroquinolones
HET-CAM-UV model
Phototoxicity |
| Issue Date: | May-2006 |
| Publisher: | CSIR |
| Abstract: | Fluoroquinolones (FQs) are
extensively used in bacterial keratitis and other intraocular infections. Since
eye is constantly exposed to light, incidence of ocular phototoxicity due to
commonly used FQs is of great interest for their safe use. Phototoxicity of
commonly used FQs (ciprofloxacin, lomefloxacin, pefloxacin, ofloxacin,
sparfloxacin and gatifloxacin), has been evaluated by using HET-CAM-UV model
(Photo Hen Egg Test-C Chorioallantoic Membrane model). This study was further
extended by adding lomefloxacin dissolved in bovine vitreous (0.5ml) on the
chorioallantoic membrane (CAM). Using a standard scale, the phototoxic damage
was assessed at different time intervals. Respective controls were kept in dark
to distinguish the toxicity of the drugs per
se. The results showed that the phototoxicity induced by lomefloxacin was
very high followed by gatifloxacin and sparfloxacin and least for other drugs
studied. Interestingly, lomefloxacin along with vitreous showed significantly
low phototoxicity. This could be due to the antioxidant property of ascorbic
acid present in the vitreous. |
| Page(s): | 387-391 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(05) [May 2006]
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