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IJEB Vol.44(05) [May 2006] >


Title: Differential acetylcholinesterase activity in rat cerebrum, cerebellum and hypothalamus
Authors: Roy (Pal), Rini
Chaudhuri, Aditi Nag
Keywords: Acetylcholinesterase activity
Cerebrum
Cerebellum
Hypothalamus
Rat
Issue Date: May-2006
Publisher: CSIR
Abstract: Acetylcholinesterase (AChE) has been purified from three different regions of rat brain using Sephadex┬« G 200 column. SDS PAGE (6%) showed single band for the purified AChE fractions. Purified and lyophilized AChE from different (NH4)2SO4 precipitated fractions of three brain parts were utilized for in vitro enzyme kinetics using Dimethoate (Dmt) as inhibitor. Km values for cerebellum and hypothalamus were almost similar whereas cerebrum showed a different Km value compared to other two regions. With the drug Rivastigmine it was found that % G1 and G4 forms of AChE in three different parts of brain are different.
Page(s): 381-386
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(05) [May 2006]

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