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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(05) [May 2006] >
| Title: | β–Adrenoceptor agonist treatment reverses denervation atrophy with augmentation of collagen proliferation in denervated mice gastrocnemius muscle |
| Authors: | Kumar, Rakesh
Katoch, Surender S
Sharma, Sushma |
| Keywords: |  -Adrenoceptor agonist
Collagen
Denervation
Gastrocnemius
Isoproterenol |
| Issue Date: | May-2006 |
| Publisher: | CSIR |
| Abstract: | Daily oral
administration of isoproterenol hydrochloride (60 mg/kg body weight; for 30
days) a b-receptor agonist to normal innervated
and denervated adult male Swiss albino mice confirmed its ability to induce
skeletal muscle hypertrophy and reverse denervation atrophy respectively.
Measurement of total tissue proteins and dry muscle mass showed 15-17% increase
with 6% rise of hypertrophy index in gastrocnemius muscle. Hydroxyproline assay
employed to measure the total tissue collagen exhibited 45% increase in
collagen in normal innervated gastrocnemius muscle in response to b agonist treatment. -adrenoceptor agonist ameliorated denervation
atrophy along with further increase in collagen content of denervated
gastrocnemius muscle. |
| Page(s): | 371-376 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(05) [May 2006]
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